An antagonist of agonist-induced PPARγ transcriptional activity
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SR 202

Item No. 21846

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
phosphoric acid, (4-chlorophenyl)(dimethoxyphosphinyl)methyl dimethyl ester
CAS Number
76541-72-5
Molecular Formula
C11H17ClO7P2
Formula Weight
358.7
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Water: 100 mM
λmax
226 nm
SMILES
ClC1=CC=C(C=C1)C(OP(OC)(OC)=O)P(OC)(OC)=O
InChi Code
InChI=1S/C11H17ClO7P2/c1-15-20(13,16-2)11(19-21(14,17-3)18-4)9-5-7-10(12)8-6-9/h5-8,11H,1-4H3
InChi Key
VQHUQHAPWMNBLP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $50

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    5 mg

    $147

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    SR 202 is an antagonist of peroxisome proliferator-activated receptor γ (PPARγ) transcriptional activity induced by troglitazone (Item No. 71750; IC50 = 140 µM) but not of basal PPARγ activity.1 It is selective for PPARγ, not affecting basal or agonist-induced transcriptional activity of PPARα, PPARβ, or the farnesoid X receptor (FXR). It inhibits PPARγ-dependent differentiation of preadipocyte 3T3-L1 cells in a dose-dependent manner. SR 202 (400 mg/kg) decreases the amount of weight gained and white adipose tissue mass accumulated by mice fed a standard or high-fat diet for ten weeks and is associated with lower PPARγ mRNA levels. It protects against high-fat diet-induced insulin resistance in wild-type mice and improves insulin sensitivity in ob/ob mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rieusset, J., Touri, F., Michalik, L., et al. A new selective peroxisome proliferator-activated receptor γ antagonist with antiobesity and antidiabetic activity. Mol. Endocrinol. 16(11), 2628-2644 (2002).