A CCR4 antagonist
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

CCR4 Antagonist (hydrochloride)

Item No. 21885

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine, dihydrochloride
CAS Number
1784252-84-1
Synonyms
  • C-021
Molecular Formula
C27H41N5O2 • 2HCl
Formula Weight
540.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 25 mg/mlEthanol: 5 mg/ml
λmax
214, 248 nm
SMILES
COC(C(OC)=C1)=CC2=C1C(NC3CCCCCC3)=NC(N4CCC(N5CCCCC5)CC4)=N2.Cl.Cl
InChi Code
InChI=1S/C27H41N5O2.2ClH/c1-33-24-18-22-23(19-25(24)34-2)29-27(30-26(22)28-20-10-6-3-4-7-11-20)32-16-12-21(13-17-32)31-14-8-5-9-15-31;;/h18-21H,3-17H2,1-2H3,(H,28,29,30);2*1H
InChi Key
GKJKNYQUFAPLOQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $65

    Add

    5 mg

    $203

    Add
    Product Description

    Chemokine (C-C motif) receptor 4 (CCR4) antagonist is an antagonist of CCR4.1 It inhibits activation of CCR4 by chemokine (C-C motif) ligand 22 (CCL22) in a [35S]GTPγS assay and also inhibits chemotaxis in human and mouse CCR4-expressing B300-19 cells (IC50s = 18, 140, and 39 nM, respectively). CCR4 antagonist inhibits microglial activation in the cortex in a mouse model of hepatic encephalopathy induced by the neurotoxin azoxymethane when administered at a dose of 1 mg/kg per day.2 It reduces azoxymethane-induced increases in Il6 and Il1b expression in mouse cortex. CCR4 antagonist reduces mechanical and thermal sensitivity in a mouse model of type I diabetes induced by streptozotocin (Item No. 13104) when administered intrathecally at doses ranging from 10 to 30 µg/animal.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yokoyama, K., Ishikawa, N., Igarashi, S., et al. Discovery of potent CCR4 antagonists: Synthesis and structure-activity relationship study of 2,4-diaminoquinazolines. Bioorg. Med. Chem. 16(14), 7021-7032 (2008).

    2. McMillin, M., Frampton, G., Thompson, M., et al. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J. Neuroinflammation 11, 121 (2014).

    3. Bogacka, J., Ciapała, K., Pawlik, K., et al. Blockade of CCR4 diminishes hypersensitivity and enhances opioid analgesia - Evidence from a mouse model of diabetic neuropathy. Neuroscience 441, 77-92 (2020).