An insecticidal antibiotic
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Milbemectin

Item No. 22003

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
Milbemycin A3: (6R,25R)-5-O-demethyl-28-deoxy-6,28-epoxy-25-methyl-milbemycin B

Milbemycin A4: (6R,25R)-5-O-demethyl-28-deoxy-6,28-epoxy-25-ethyl-milbemycin B
CAS Number
1799297-76-9
Synonyms
  • Milbemycin A3 (~30%) and Milbemycin A4 (~70%) Mixture
Molecular Formula
C31H44O7 (A3) and C32H46O7 (A4)
Purity
≥95% (mixture)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: SolubleDMSO: SolubleEthanol: SolubleMethanol: Soluble
λmax
245 nm
SMILES
C/C(C[C@@H](C)/C=C/C=C(CO1)/[C@@]([C@@]1([H])[C@H](O)C(C)=C2)(O)[C@]2([H])C3=O)=C\C[C@]4([H])C[C@@](O3)([H])C[C@@]5(O[C@]([H])(C)[C@@H](C)CC5)O4.C/C(C[C@@H](C)/C=C/C=C(CO6)/[C@@]([C@@]6([H])[C@H](O)C(C)=C7)(O)[C@]7([H])C8=O)=C\C[C@]9([H])C[C@@](O8)([H])C[C@@]%10(O[C@]([H])(CC)[C@@H](C)CC%10)O9
InChi Code
InChI=1S/C32H46O7.C31H44O7/c1-6-27-21(4)12-13-31(39-27)17-25-16-24(38-31)11-10-20(3)14-19(2)8-7-9-23-18-36-29-28(33)22(5)15-26(30(34)37-25)32(23,29)35;1-18-7-6-8-23-17-35-28-27(32)21(4)14-26(31(23,28)34)29(33)36-25-15-24(10-9-19(2)13-18)38-30(16-25)12-11-20(3)22(5)37-30/h7-10,15,19,21,24-29,33,35H,6,11-14,16-18H2,1-5H3;6-9,14,18,20,22,24-28,32,34H,10-13,15-17H2,1-5H3/b8-7+,20-10+,23-9+;7-6+,19-9+,23-8+/t19-,21-,24+,25-,26-,27+,28+,29+,31+,32+;18-,20-,22+,24+,25-,26-,27+,28+,30-,31+/m00/s1
InChi Key
YSKQMQHQUJEAQB-YPPYQCCRSA-N
Origin
Bacterium/Streptomyces hygroscopicus, Semi-synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $229

    Add

    25 mg

    $802

    Add
    Cayman Chemical
    Visit Our Environmental Toxicology Resource Center

    Explore additional resources to study natural toxins, pollutants including PFAS and 6-PPD-Q, and their biological effects.

    ENVIRONMENTAL TOXICOLOGY TOOLS & SERVICES
    Product Description

    Milbemectin is a mixture of milbemycin A3 (30%; Item No. 18360) and milbemycin A4 (70%; Item No. 17155) that has acaricidal and nematocidal activity against adult spider mites, spider mite eggs, and C. elegans with IC50 values of 5.3, 41.1, and 9.5 µg/ml, respectively.1 It acts as an allosteric agonist of the Drosophila RDL GABA receptor.2 It is also effective against the pinewood nematode, B. xylophilus with an LC20 of 0.0781 mg/liter.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yang, L.Y., Wang, J.D., Zhang, J., et al. New nemadectin congeners with acaricidal and nematocidal activity from Streptomyces microflavus neau3 Y-3. Bioorg. Med. Chem. Lett. 23(20), 5710-5713 (2013).

    2. Nakao, T., Banba, S., and Hirase, K. Comparison between the modes of action of novel meta-diamide and macrocyclic lactone insecticides on the RDL GABA receptor. Pestic. Biochem. Physiol. 120, 101-108 (2015).

    3. Bi, Z., Gong, Y., Huang, X., et al. Efficacy of four nematicides against the reproduction and development of pinewood nematode, Bursaphelenchus xylophilus. J. Nematol. 47(2), 126-132 (2015).