A HAT inhibitor
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MG149

Item No. 22135

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[2-(4-heptylphenyl)ethyl]-6-hydroxy-benzoic acid
CAS Number
1243583-85-8
Molecular Formula
C22H28O3
Formula Weight
340.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
SMILES
OC1=C(C(O)=O)C(CCC2=CC=C(CCCCCCC)C=C2)=CC=C1
InChi Code
InChI=1S/C22H28O3/c1-2-3-4-5-6-8-17-11-13-18(14-12-17)15-16-19-9-7-10-20(23)21(19)22(24)25/h7,9-14,23H,2-6,8,15-16H2,1H3,(H,24,25)
InChi Key
WBHQYBZRTAEHRR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $48

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    5 mg

    $184

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    10 mg

    $319

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    25 mg

    $627

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    Product Description

    MG149 is a histone acetyltransferase (HAT) inhibitor with IC50 values of 74 and 47 μM, for human recombinant Tip60 and males absent on the first (MOF) HATs, respectively.1,2 MG149 targets the acetyl-CoA binding site and inhibits acetyltransferase activity in the nuclear extract from murine hippocampus, amygdala, and prefrontal cortex.3 MG149 also inhibits the p53 and NF-κB pathways.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Legartová, S., Stixová, L., Strnad, H., et al. Basic nuclear processes affected by histone acetyltransferases and histone deacetylase inhibitors. Epigenomics 5(4), 379-396 (2013).

    2. Su, J., Wang, F., Cai, Y., et al. The functional analysis of histone acetyltransferase MOF in tumorigenesis. Int. J. Mol. Sci. 17(1), (2016).

    3. Ghizzoni, M., Wu, J., Gao, T., et al. 6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site. Eur. J. Med. Chem. 47(1), 337-344 (2012).