A metabolite of bufuralol
Related Products
Parent Compound(s)
17794Bufuralol (hydrochloride)
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1'-hydroxy Bufuralol

Item No. 22160

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α2-[[(1,1-dimethylethyl)amino]methyl]-α7-methyl-2,7-benzofurandimethanol
CAS Number
57704-16-2
Synonyms
  • Ro 03-7410
Molecular Formula
C16H23NO3
Formula Weight
277.4
Purity
≥97%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleMethanol: Slightly soluble
SMILES
CC(O)C1=C(OC(C(O)CNC(C)(C)C)=C2)C2=CC=C1
InChi Code
InChI=1S/C16H23NO3/c1-10(18)12-7-5-6-11-8-14(20-15(11)12)13(19)9-17-16(2,3)4/h5-8,10,13,17-19H,9H2,1-4H3
InChi Key
GTYMTYBCXVOBBB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $208

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    1 mg

    $395

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    Product Description

    1’-hydroxy Bufuralol is a metabolite of bufuralol (Item No. 17794). Bufuralol is metabolized by the cytochrome P450 isoforms 2D1 and 2D2 (CYP2D1/2); therefore, quantification of the bufuralol metabolite, 1’-hydroxy bufuralol, can be used to determine CYP2D1/2 enzyme activity in humans and rats.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Daskalopoulos, E.P., Lang, M.A., Marselos, M., et al. D₂-dopaminergic receptor-linked pathways: Critical regulators of CYP3A, CYP2C, and CYP2D. Mol. Pharmacol. 82(4), 668-678 (2012).

    2. Yamazaki, H., Guo, Z., Persmark, M., et al. Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes. Mol. Pharmacol. 46(3), 568-577 (1994).

    Product Citations

    Negoro, R., Tasaka, M., Deguchi, S., et al. Generation of HepG2 cells with high expression of multiple drug-metabolizing enzymes for drug discovery research using a PITCh system. Cells 11(10), 1677 (2022).