An ACE inhibitor
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Pro-drug Form(s)
18241Temocapril (hydrochloride)
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Temocaprilat

Item No. 22169

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S,6R)-6-[[(1S)-1-carboxy-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic acid
CAS Number
110221-53-9
Synonyms
  • CS 622 Diacid
  • RS 5139
  • Temocapril Diacid
Molecular Formula
C21H24N2O5S2
Formula Weight
448.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 3 mg/mlEthanol: Partially solublePBS (pH 7.2): 5 mg/ml
λmax
234 nm
SMILES
OC([C@@H](N[C@H]1CS[C@H](C2=CC=CS2)CN(CC(O)=O)C1=O)CCC3=CC=CC=C3)=O
InChi Code
InChI=1S/C21H24N2O5S2/c24-19(25)12-23-11-18(17-7-4-10-29-17)30-13-16(20(23)26)22-15(21(27)28)9-8-14-5-2-1-3-6-14/h1-7,10,15-16,18,22H,8-9,11-13H2,(H,24,25)(H,27,28)/t15-,16-,18-/m0/s1
InChi Key
KZVWEOXAPZXAFB-BQFCYCMXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $134

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    1 mg

    $240

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    5 mg

    $795

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Temocaprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 3.6 nM for rabbit lung ACE).1 It inhibits contraction of isolated rat aorta induced by angiotensin I (Item No. 24737) with an IC50 value of 7.6 nM. Temocaprilat (1-30 μg/kg, i.v.) inhibits angiotensin I-induced pressor responses in anesthetized rats in a dose-dependent manner.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Oizumi, K., Koike, H., Sada, T., et al. Pharmacological profiles of CS-622, a novel angiotensin converting enzyme inhibitor. Jpn. J. Pharmacol. 48(3), 349-356 (1988).