An active metabolite of sunitinib
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Parent Compound(s)
13159Sunitinib (malate)
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N-desethyl Sunitinib

Item No. 22292

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(ethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl- 1H-pyrrole-3-carboxamide
CAS Number
356068-97-8
Synonyms
  • SU 12662
Molecular Formula
C20H23FN4O2
Formula Weight
370.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: slightly solublePBS (pH 7.2): slightly soluble
λmax
268, 429 nm
SMILES
CC1=C(/C=C2C(NC3=C\2C=C(F)C=C3)=O)NC(C)=C1C(NCCNCC)=O
InChi Code
InChI=1S/C20H23FN4O2/c1-4-22-7-8-23-20(27)18-11(2)17(24-12(18)3)10-15-14-9-13(21)5-6-16(14)25-19(15)26/h5-6,9-10,22,24H,4,7-8H2,1-3H3,(H,23,27)(H,25,26)/b15-10-
InChi Key
LIZNIAKSBJKPQC-GDNBJRDFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $41

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    1 mg

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    5 mg

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    Product Description

    N-desethyl Sunitinib is an active metabolite of sunitinib (Item No. 13159), a small molecule, multi-targeted receptor tyrosine kinase inhibitor.1,2 N-desethyl Sunitinib is formed when sunitinib undergoes N-de-ethylation by the cytochrome P450 (CYP) isomer CYP3A4.2 N-desethyl Sunitinib is pharmacologically active having similar inhibitory activity to sunitinib.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. O'Farrell, A.M., Abrams, T.J., Yuen, H.A., et al. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood 101(9), 3597-3605 (2003).

    2. Yu, H., Steeghs, N., Kloth, J.S.L., et al. Integrated semi-physiological pharmacokinetic model for both sunitinib and its active metabolite SU12662. Br. J. Clin. Pharmacol. 79(5), 809-819 (2015).