A xanthone glucoside with diverse biological activities
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Mangiferin

Item No. 22360

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-β-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one
CAS Number
4773-96-0
Synonyms
  • NSC 248870
Molecular Formula
C19H18O11
Formula Weight
422.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 5 mg/mlEthanol: slightly soluble
λmax
242, 258, 316, 364 nm
SMILES
OC1=C(O)C=C(OC(C=C(O)C([C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)=C3O)=C3C4=O)C4=C1
InChi Code
InChI=1S/C19H18O11/c20-4-11-15(25)17(27)18(28)19(30-11)12-8(23)3-10-13(16(12)26)14(24)5-1-6(21)7(22)2-9(5)29-10/h1-3,11,15,17-23,25-28H,4H2/t11-,15-,17+,18-,19+/m1/s1
InChi Key
AEDDIBAIWPIIBD-ZJKJAXBQSA-N
Origin
Plant/Mangifera indica L.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $46

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    1 g

    $333

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Mangiferin is a xanthone glucoside that has been found in M. indica with diverse biological activities.1 It increases survival of HIV-1-infected MT-2 human leukemia cells (EC50 = 3.59 μg/ml).2 In an ascitic fibrosarcoma (AFS) mouse xenograft model, mangiferin (10 μg/g) inhibits tumor growth by 47% at 15 days post inoculation and increases lifespan by 38% relative to control. Mangiferin (50 mg/kg, p.o.) reduces the production of hydrogen peroxide induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mouse peritoneal macrophages by 40% ex vivo.3 It also decreases TPA-induced DNA fragmentation in mouse liver and brain by 35 and 22%, respectively. Mangiferin (0.25-2 mg/kg, i.p.) dose-dependently increases survival of γ-irradiated mice.4 Mangiferin (10 mg/kg, i.p.) reduces fasting plasma glucose, total cholesterol, triglycerides, and LDL cholesterol (LDL-C) levels in a rat model of diabetes induced by streptozotocin (Item No. 13104) by 50, 57, 38.5, and 70%, respectively.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Muruganandan, S., Srinivasan, K., Gupta, S., et al. Effect of mangiferin on hyperglycemia and atherogenicity in streptozotocin diabetic rats. J. Ethnopharmacol. 97(3), 497-501 (2005).

    2. Guha, S., Ghosal, S., and Chattopadhyay, U. Antitumor, immunomodulatory and anti-HIV effect of mangiferin, a naturally occurring glucosylxanthone. Chemotherapy 42(6), 443-451 (1996).

    3. Sánchez, G.M., Re, L., Giuliani, A., et al. Protective effects of Mangifera indica L. extract, mangiferin and selected antioxidants against TPA-induced biomolecules oxidation and peritoneal macrophage activation in mice. Pharmacol. Res. 42(6), 565-573 (2000).

    4. Jagetia, G.C., and Baliga, M.S. Radioprotection by mangiferin in DBAxC57BL mice: A preliminary study. Phytomedicine 12(3), 209-215 (2005).