An ebastine metabolite
Related Products
Active Metabolite(s)
23076Carebastine
Parent Compound(s)
15372Ebastine
Technical Support & Resources

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Hydroxyebastine

Item No. 22379

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[4-(diphenylmethoxy)-1-piperidinyl]-1-[4-(2-hydroxy-1,1-dimethylethyl)phenyl]-1-butanone
CAS Number
210686-41-2
Molecular Formula
C32H39NO3
Formula Weight
485.7
Purity
≥87%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: soluble
SMILES
O=C(C1=CC=C(C(C)(C)CO)C=C1)CCCN(CC2)CCC2OC(C3=CC=CC=C3)C4=CC=CC=C4
InChi Code
InChI=1S/C32H39NO3/c1-32(2,24-34)28-17-15-25(16-18-28)30(35)14-9-21-33-22-19-29(20-23-33)36-31(26-10-5-3-6-11-26)27-12-7-4-8-13-27/h3-8,10-13,15-18,29,31,34H,9,14,19-24H2,1-2H3
InChi Key
UDZUMQUGNZBRMN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

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    Cayman Chemical
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    Product Description

    Hydroxyebastine is an ebastine (Item No. 15372) metabolite.1,2 Ebastine undergoes rapid first-pass metabolism by the cytochrome P450 isoform CYP2J2 to form hydroxyebastine which is then metabolized by CYP2J2 and CYP3A4 to form carebastine.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Abou-Gharbia, M., Moyer, J.A., Nielsen, S.T., et al. New antihistamines: Substituted piperazine and piperidine derivatives as novel H1-antagonists. J. Med. Chem. 38(20), 4026-4032 (1995).

    2. Liu, K.-H., Kim, M.-G., Lee, D.-J., et al. Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: Major roles for CYP2J2 and CYP3A. Drug. Metab. Dispos. 34(11), 1793-1797 (2006).