A metabolite of 4-hydroxy propranolol
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4-hydroxy Propranolol β-D-Glucuronide

Item No. 22383

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-1-naphthalenyl β-D-glucopyranosiduronic acid
CAS Number
94731-13-2
Molecular Formula
C22H29NO9
Formula Weight
451.5
Purity
≥95% (mixture of diastereomers)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: soluble
SMILES
OC(CNC(C)C)COC1=CC=C(O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O2)C3=C1C=CC=C3
InChi Code
InChI=1S/C22H29NO9/c1-11(2)23-9-12(24)10-30-15-7-8-16(14-6-4-3-5-13(14)15)31-22-19(27)17(25)18(26)20(32-22)21(28)29/h3-8,11-12,17-20,22-27H,9-10H2,1-2H3,(H,28,29)/t12?,17-,18-,19+,20-,22+/m0/s1
InChi Key
GCESUDQAKCEBSY-MBOKBCRSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $192

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    1 mg

    $322

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    Product Description

    4-hydroxy Propranolol β-D-glucuronide is a metabolite of the β-adrenergic receptor antagonist 4-hydroxy propranolol (Item No. 18630).1 It is formed from propranolol (Item No. 23349) via a 4-hydroxy propranolol intermediate by the UDP-glucuronosyltransferase (UGT) isoforms UGT1A9 and UGT2A1.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yang, F., Liu, S., Wolber, G., et al. Complete reaction phenotyping of propranolol and 4-hydroxypropranolol with the 19 enzymes of the human UGT1 and UGT2 families. Int. J. Mol. Sci. 23(13), 7476 (2022).