An internal standard for the quantification of telmisartan
Related Products
Unlabeled Version(s)
11615Telmisartan
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Telmisartan-d3

Item No. 22568

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4'-((7'-methyl-1-(methyl-d3)-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid
CAS Number
1189889-44-8
Molecular Formula
C33H27D3N4O2
Formula Weight
517.6
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: SolubleDMSO: Soluble
SMILES
CC1=CC(C2=NC3=C(C=CC=C3)N2C([2H])([2H])[2H])=CC4=C1N=C(CCC)N4CC5=CC=C(C6=CC=CC=C6C(O)=O)C=C5
InChi Code
InChI=1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39)/i3D3
InChi Key
RMMXLENWKUUMAY-HPRDVNIFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $196

    Add

    1 mg

    $370

    Add
    Product Description

    Telmisartan-d3 is intended for use as an internal standard for the quantification of telmisartan (Item No. 11615) by GC- or LC-MS. Telmisartan is a nonpeptide angiotensin (AT) II receptor antagonist which selectively and insurmountably inhibits the AT II receptor subtype AT1 (Ki = 3.7 nM).1 It also acts as a partial agonist of peroxisome proliferator-activated receptor gamma (PPARγ), activating the receptor to 25-30% of that produced by the full agonist rosiglitazone (Item No. 71740; EC50 = 4.5 μM).2 Through these actions, telmisartan potently reduces blood pressure in various animal models of hypertension, diminishing cardiac hypertrophy, cardiovascular and renal risk, and glomerulosclerosis.3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wienen, W., Hauel, N., Van Meel, J.C.A., et al. Pharmacological characterization of the novel nonpeptide angiotensin II receptor antagonist, BIBR 277. Br. J. Pharmacol. 110(1), 245-252 (1993).

    2. Benson, S.C., Pershadsingh, H.A., Ho, C.I., et al. Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARγ-modulating activity. Hypertension 43(5), 993-1002 (2004).

    3. McClellan, K.J., and Markham, A. Telmisartan. Drugs 56(6), 1039-1044 (1998).

    4. Jugdutt, B.I. Clinical effectiveness of telmisartan alone or in combination therapy for controlling blood pressure and vascular risk in the elderly. Clin. Interv. Aging 5, 403-416 (2010).

    5. Schmieder, R.E., Bakris, G., and Weir, M.R. Telmisartan in incipient and overt diabetic renal disease. J. Nephrol. 24(3), 263-273 (2011).