A uricase inhibitor
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Product Categories

Product Type

Small Molecule Modulators
Small Molecule Inhibitors

Research Area

Cancer

Oxonic Acid (potassium salt)

Item No. 22586

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,4,5,6-tetrahydro-4,6-dioxo-1,3,5-triazine-2-carboxylic acid, monopotassium salt
CAS Number
2207-75-2
Synonyms
  • Allantoxanic Acid
  • Potassium oxonate
Molecular Formula
C4H2N3O4 • K
Formula Weight
195.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 0.3 mg/ml
λmax
238 nm
SMILES
O=C(N=C(C([O-])=O)N1)NC1=O.[K+]
InChi Code
InChI=1S/C4H3N3O4.K/c8-2(9)1-5-3(10)7-4(11)6-1;/h(H,8,9)(H2,5,6,7,10,11);/q;+1/p-1
InChi Key
IAPCTXZQXAVYNG-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $36

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    10 g

    $68

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    25 g

    $145

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    50 g

    $268

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    Cayman Chemical
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    Product Description

    Oxonic acid is a uricase inhibitor that prevents metabolism and excretion of uric acid (Item No. 16219) and induces embryotoxicity and nephrotoxicity in rats.1 It is a component of S-1, a mixture containing a prodrug of the antitumor agent 5-fluorouracil (5-FU; Item No. 14416), that suppresses the gastrointestinal toxicity of 5-FU without inhibiting its antitumor activity in rats.2 Formulations containing oxonic acid have been used to treat gastric, pancreatic, lung, head, neck, and breast carcinomas.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gralla, E.J., and Crelin, E.S. Oxonic acid and fetal development: I. Embryotoxicity in mice. Toxicology 6(3), 289-297 (1976).

    2. Yoshisue, K., Masuda, H., Matsushima, E., et al. Tissue distribution and biotransformation of potassium oxonate after oral administration of a novel antitumor agent (drug combination of tegafur, 5-chloro-2,4-dihydroxypyridine, and potassium oxonate) to rats. Drug. Metab. Dispos. 28(10), 1162-1167 (2000).

    3. Chhetri, P., Giri, A., Shakya, S., et al. Current development of anti-cancer drug S-1. J. Clin. Diagn. Res. 10(11), XE01-XE05 (2016).