An organophosphate insecticide
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Labeled Version(s)
39561Malathion-d10 39262Malathion-d6
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Malathion

Item No. 22998

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(dimethoxyphosphinothioyl)thio]-butanedioic acid, 1,4-diethyl ester
CAS Number
121-75-5
Synonyms
  • NSC 6524
Molecular Formula
C10H19O6PS2
Formula Weight
330.4
Purity
≥95%
Formulation (Request formulation change)
An oil
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly SolubleWater: Very Slightly Soluble
SMILES
CCOC(C(SP(OC)(OC)=S)CC(OCC)=O)=O
InChi Code
InChI=1S/C10H19O6PS2/c1-5-15-9(11)7-8(10(12)16-6-2)19-17(18,13-3)14-4/h8H,5-7H2,1-4H3
InChi Key
JXSJBGJIGXNWCI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    50 mg

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    Product Description

    Malathion is an organophosphate insecticide that inhibits acetylcholinesterase (IC50s = 370 and 160 µM for free and immobilized AChE, respectively, from bovine erythrocytes).1 It is ovicidal and adulticidal to laboratory colonies of body lice when used at concentrations of 0.001 and 0.05%, respectively.2 It is toxic to rats (LD50 = 750 mg/kg) and teratogenic to zebrafish when used at concentrations ranging from 2 to 3 mg/L.3,4 Formulations containing malathion have been used in the treatment of lice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Krstić, D.Z., Ĉolović, M., Kralj, M.B., et al. Inhibition of AChE by malathion and some structurally similar compounds. J. Enzyme Inhib. Med. Chem. 23(4), 562-573 (2008).

    2. Cole, M.M., and Burden, G.S. Phosphorus compounds as ovicides and adulticides against body lice. J. Econ. Entomol. 49(6), 747-750 (1956).

    3. DuBois, K.P., Doull, J., Deroin, J., et al. Toxicity and mechanism of action of some new insecticidal thionophosphates. Arch. Ind. Hyg. Occup. Med. 8(4), 350-358 (1953).

    4. Cook, L.W., Paradise, C.J., and Lom, B. The pesticide malathion reduces survival and growth in developing zebrafish. Environ. Toxicol. Chem. 24(7), 1745-1750 (2005).