An internal standard for the quantification of malathion
Related Products
Alternative(s)
39561Malathion-d10
Unlabeled Version(s)
22998Malathion
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Malathion-d6

Item No. 39262

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,4-diethyl 2-[[di(methoxy-d3)phosphinothioyl]thio]butanedioate
CAS Number
1189877-72-2
Molecular Formula
C10H13D6O6PS2
Formula Weight
336.4
Purity
≥99% deuterated forms (d1-d6)
Formulation (Request formulation change)
A 10 mg/ml solution in methanol
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly solubleMethanol: Slightly solubleWater: Very slightly soluble
SMILES
CCOC(C(SP(OC([2H])([2H])[2H])(OC([2H])([2H])[2H])=S)CC(OCC)=O)=O
InChi Code
InChI=1S/C10H19O6PS2/c1-5-15-9(11)7-8(10(12)16-6-2)19-17(18,13-3)14-4/h8H,5-7H2,1-4H3/i3D3,4D3
InChi Key
JXSJBGJIGXNWCI-LIJFRPJRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Malathion-d6 is intended for use as an internal standard for the quantification of malathion (Item No. 22998) by GC- or LC-MS. Malathion is an organophosphate insecticide that inhibits acetylcholinesterase (AChE; IC50s = 370 and 160 µM for free and immobilized AChE, respectively, from bovine erythrocytes).1 It is ovicidal and adulticidal to laboratory colonies of body lice when used at concentrations of 0.001 and 0.05%, respectively.2 It is toxic to rats (LD50 = 750 mg/kg) and teratogenic to zebrafish when used at concentrations ranging from 2 to 3 mg/L.3,4 Formulations containing malathion have been used in the treatment of lice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Krstić, D.Z., Ĉolović, M., Kralj, M.B., et al. Inhibition of AChE by malathion and some structurally similar compounds. J. Enzyme Inhib. Med. Chem. 23(4), 562-573 (2008).

    2. Cole, M.M., and Burden, G.S. Phosphorus compounds as ovicides and adulticides against body lice. J. Econ. Entomol. 49(6), 747-750 (1956).

    3. DuBois, K.P., Doull, J., Deroin, J., et al. Toxicity and mechanism of action of some new insecticidal thionophosphates. Arch. Ind. Hyg. Occup. Med. 8(4), 350-358 (1953).

    4. Cook, L.W., Paradise, C.J., and Lom, B. The pesticide malathion reduces survival and growth in developing zebrafish. Environ. Toxicol. Chem. 24(7), 1745-1750 (2005).