A triacylglycerol
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Labeled Version(s)
430751,2,3-Trilauroyl-d15 Glycerol
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1,2,3-Trilauroyl Glycerol

Item No. 23336

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
dodecanoic acid, 1,1',1''-(1,2,3-propanetriyl) ester
CAS Number
538-24-9
Synonyms
  • Glycerol Tridodecanoate
  • Glycerol Trilaurate
  • NSC 4061
  • TG(12:0/12:0/12:0)
  • Tridodecanoin
  • Tridodecanoyl Glycerol
  • Trilaurin
Molecular Formula
C39H74O6
Formula Weight
639.0
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlEthanol: 1 mg/ml
SMILES
O=C(CCCCCCCCCCC)OCC(OC(CCCCCCCCCCC)=O)COC(CCCCCCCCCCC)=O
InChi Code
InChI=1S/C39H74O6/c1-4-7-10-13-16-19-22-25-28-31-37(40)43-34-36(45-39(42)33-30-27-24-21-18-15-12-9-6-3)35-44-38(41)32-29-26-23-20-17-14-11-8-5-2/h36H,4-35H2,1-3H3
InChi Key
VMPHSYLJUKZBJJ-UHFFFAOYSA-N
Side Chain Carbon Sum
36:0
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 g

    $81

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    Product Description

    1,2,3-Trilauroyl glycerol is a triacylglycerol that contains lauric acid (Item No. 10006626) at the sn-1, sn-2, and sn-3 positions and is a component of coconut and seed oils.1,2 It increases the activity of HMG-CoA reductase in rat intestine and the production of cholesterol in the rat jejunal and ileal epithelium when administered at a dose of 10% (w/w) in the diet.3 A nanoemulsion of 1,2,3-trilauroyl glycerol (0.2%, w/v) is virucidal against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and H1N1 influenza A virus in infected MDCK cells.4 1,2,3-Trilauroyl glycerol has been used in the formation of solid lipid nanoparticles (SLNs) for the delivery of paclitaxel (Item No. 10461) in SKOV3 ovarian cancer cells.5 Formulations containing 1,2,3-trilauroyl glycerol have been used in cosmetics as skin conditioners and thickening agents.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Komaram, A.C., Anjaneyulu, E., Goswami, K., et al. Detection and quantification of palmolein and palm kernel oil added as adulterant in coconut oil based on triacylglycerol profile. J. Food Sci. Technol. 58(11), 4420-4428 (2021).

    2. Litchfield, C., Miller, E., Harlow, R.D., et al. The triglyceride composition of 17 seed fats rich in octanoic, decanoic, or lauric acid. Lipids 2(4), 345-350 (1967).

    3. Oku, H., and Sugano, M. Dietary fat dependence of intestinal 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity in rats. J. Nutr. 115(7), 880-889 (1985).

    4. Weerapol, Y., Manmuan, S., Limmatvapirat, S., et al. Enhancing the efficacy of monolaurin against SARS-CoV-2 and influenza A (H1N1) with a nanoemulsion formulation. OpenNano 17, 100207 (2024).

    5. Xu, W., Lim, S.-J., and Lee, M.-K. Cellular uptake and antitumour activity of paclitaxel incorporated into trilaurin-based solid lipid nanoparticles in ovarian cancer. J. Microencapsul. 30(8), 755-761 (2013).