An internal standard for the quantification of 1,2,3-trilauroyl glycerol
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Unlabeled Version(s)
233361,2,3-Trilauroyl Glycerol
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1,2,3-Trilauroyl-d15 Glycerol

Item No. 43075

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
propane-1,2,3-triyl tris(dodecanoate-11,11,12,12,12-d5)
CAS Number
1219805-25-0
Synonyms
  • Glycerol Tridodecanoate-d15
  • Glycerol Trilaurate-d15
  • TG(12:0-d5/12:0-d5/12:0-d5)
  • Tridodecanoin-d15
  • Tridodecanoyl-d15 Glycerol
  • Trilaurin-d15
Molecular Formula
C39H59D15O6
Formula Weight
654.1
Purity
≥99% deuterated forms (d1-d15)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(CCCCCCCCCC(C([2H])([2H])[2H])([2H])[2H])OCC(OC(CCCCCCCCCC([2H])([2H])C([2H])([2H])[2H])=O)COC(CCCCCCCCCC([2H])([2H])C([2H])([2H])[2H])=O
InChi Code
InChI=1S/C39H74O6/c1-4-7-10-13-16-19-22-25-28-31-37(40)43-34-36(45-39(42)33-30-27-24-21-18-15-12-9-6-3)35-44-38(41)32-29-26-23-20-17-14-11-8-5-2/h36H,4-35H2,1-3H3/i1D3,2D3,3D3,4D2,5D2,6D2
InChi Key
VMPHSYLJUKZBJJ-NLBPYYKNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    1,2,3-Trilauroyl-d15 glycerol is intended for use as an internal standard for the quantification of 1,2,3-trilauroyl glycerol (Item No. 23336) by GC- or LC-MS. 1,2,3-Trilauroyl glycerol is a triacylglycerol that contains lauric acid (Item No. 10006626) at the sn-1, sn-2, and sn-3 positions and is a component of coconut and seed oils.1,2 It increases the activity of HMG-CoA reductase in rat intestine and the production of cholesterol in the rat jejunal and ileal epithelium when administered at a dose of 10% (w/w) in the diet.3 A nanoemulsion of 1,2,3-trilauroyl glycerol (0.2%, w/v) is virucidal against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and H1N1 influenza A virus in infected MDCK cells.4 1,2,3-Trilauroyl glycerol has been used in the formation of solid lipid nanoparticles (SLNs) for the delivery of paclitaxel (Item No. 10461) in SKOV3 ovarian cancer cells.5 Formulations containing 1,2,3-trilauroyl glycerol have been used in cosmetics as skin conditioners and thickening agents.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Komaram, A.C., Anjaneyulu, E., Goswami, K., et al. Detection and quantification of palmolein and palm kernel oil added as adulterant in coconut oil based on triacylglycerol profile. J. Food Sci. Technol. 58(11), 4420-4428 (2021).

    2. Litchfield, C., Miller, E., Harlow, R.D., et al. The triglyceride composition of 17 seed fats rich in octanoic, decanoic, or lauric acid. Lipids 2(4), 345-350 (1967).

    3. Oku, H., and Sugano, M. Dietary fat dependence of intestinal 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity in rats. J. Nutr. 115(7), 880-889 (1985).

    4. Weerapol, Y., Manmuan, S., Limmatvapirat, S., et al. Enhancing the efficacy of monolaurin against SARS-CoV-2 and influenza A (H1N1) with a nanoemulsion formulation. OpenNano 17, 100207 (2024).

    5. Xu, W., Lim, S.-J., and Lee, M.-K. Cellular uptake and antitumour activity of paclitaxel incorporated into trilaurin-based solid lipid nanoparticles in ovarian cancer. J. Microencapsul. 30(8), 755-761 (2013).