A PKD1 inhibitor
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CID-797718

Item No. 23428

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2,3,4-tetrahydro-9-hydroxy-5H-[1]benzopyrano[3,4-b]pyridin-5-one
CAS Number
370586-05-3
Molecular Formula
C12H11NO3
Formula Weight
217.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 1 mg/ml
λmax
215, 250, 347 nm
SMILES
OC1=CC=C2C(C(CCCN3)=C3C(O2)=O)=C1
InChi Code
InChI=1S/C12H11NO3/c14-7-3-4-10-9(6-7)8-2-1-5-13-11(8)12(15)16-10/h3-4,6,13-14H,1-2,5H2
InChi Key
VDZXTSOINJESSP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $153

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    10 mg

    $268

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    25 mg

    $587

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    Product Description

    CID-797718 is a protein kinase D1 (PKD1) inhibitor (IC50 = 7 µM).1 It also inhibits CDK activating kinase (CAK) and polo-like kinase 1 (PLK1) but has no activity at AKT (IC50s = 8.4, 21.9, and >50 µM, respectively). CID-797718 inhibits PKD1 activity in LNCaP cells with an IC50 value of 0.21 µM. CID7-97718 is a byproduct in the synthesis of CID-755673 (Item No. 15924).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sharlow, E.R., Giridhar, K.V., LaValle, C.R., et al. Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone. The Journal of Biological Chemisty 283(48), 33516-33526 (2008).

    2. Lavalle, C.R., Bravo-Altamirano, K., Gorodhar, K.V., et al. Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility. BMC Chem Biol. 10(5), (2010).