We collect cookies for vital website function and to better serve our customers. By continuing to browse you agree to the storing of cookies on your device. See our privacy policy for details.

AL 082D06

Item № 23455
CAS № 256925-03-8
Purity ≥98%
product image
                (CAS 256925-03-8)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $35.00 0.00
     5 mg $114.00 0.00
     10 mg $210.00 0.00

Pricing updated 2019-05-26. Prices are subject to change without notice.

Description

AL 082D06 is a non-steroidal antagonist of the glucocorticoid receptor (GR; Ki = 210 nM; EC50 = 0.3 nM in a luciferase assay).1 It is selective for GR over the androgen, progesterone, mineralocorticoid, and estrogen receptors with Ki values greater than 4, 3, 3, and 10 µM, respectively. AL 082D06 inhibits transcriptional activation induced by glucocorticoids and reverses dexamethasone-mediated repression of gene expression in a luciferase reporter assay. It blocks GR binding to DNA in vitro when induced by either dexamethasone (Item No. 11015) or mifepristone (Item No. 10006317). In contrast to the steroid-type GR antagonists ZK-299 and mifepristone, GR bound to AL 082D06 does not compete with a constitutively active GR.

Recommended Products

Related Products
View Related Product Categories
Technical Information
Formal Name
4,4'-[(2-chloro-5-nitrophenyl)methylene]bis[N,N-dimethyl]-benzenamine
CAS Number
256925-03-8
Molecular Formula
C23H24ClN3O2
Formula Weight
409.9
Purity
≥98%
Formulation
A crystalline solid
λmax
268 nm
SMILES
CN(C)C1=CC=C(C(C2=C(Cl)C=CC([N+]([O-])=O)=C2)C3=CC=C(N(C)C)C=C3)C=C1
InChI Code
InChI=1S/C23H24ClN3O2/c1-25(2)18-9-5-16(6-10-18)23(17-7-11-19(12-8-17)26(3)4)21-15-20(27(28)29)13-14-22(21)24/h5-15,23H,1-4H3
InChI Key
IPICUXHYPAMJNC-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Miner, J.N., Tyree, C., Hu, J., et al. A nonsteroidal glucocorticoid receptor antagonist Mol. Endocrinol. 17(1), 117-127 (2003).

Technical Support
Contact Us
  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Cayman Contract Services

We work with scientists to accelerate their research, drug discovery, and drug development needs through our expertise in the following areas:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

(USA and Canada Only)

Fax: (734) 971-3640