A non-steroidal glucocorticoid receptor antagonist
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AL 082D06

Item No. 23455

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,4'-[(2-chloro-5-nitrophenyl)methylene]bis[N,N-dimethyl]-benzenamine
CAS Number
256925-03-8
Molecular Formula
C23H24ClN3O2
Formula Weight
409.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS(pH7.2) (1:2): 0.33 mg/mlDMSO: 2.5 mg/ml
λmax
268 nm
SMILES
CN(C)C1=CC=C(C(C2=C(Cl)C=CC([N+]([O-])=O)=C2)C3=CC=C(N(C)C)C=C3)C=C1
InChi Code
InChI=1S/C23H24ClN3O2/c1-25(2)18-9-5-16(6-10-18)23(17-7-11-19(12-8-17)26(3)4)21-15-20(27(28)29)13-14-22(21)24/h5-15,23H,1-4H3
InChi Key
IPICUXHYPAMJNC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $154

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    10 mg

    $283

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    Product Description

    AL 082D06 is a non-steroidal antagonist of the glucocorticoid receptor (GR; Ki = 210 nM; EC50 = 0.3 nM in a luciferase assay).1 It is selective for GR over the androgen, progesterone, mineralocorticoid, and estrogen receptors with Ki values greater than 4, 3, 3, and 10 µM, respectively. AL 082D06 inhibits transcriptional activation induced by glucocorticoids and reverses dexamethasone-mediated repression of gene expression in a luciferase reporter assay. It blocks GR binding to DNA in vitro when induced by either dexamethasone (Item No. 11015) or mifepristone (Item No. 10006317). In contrast to the steroid-type GR antagonists ZK-299 and mifepristone, GR bound to AL 082D06 does not compete with a constitutively active GR.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Miner, J.N., Tyree, C., Hu, J., et al. A nonsteroidal glucocorticoid receptor antagonist. Mol. Endocrinol. 17(1), 117-127 (2003).