An NK3 receptor antagonist
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MLE-4901

Item No. 23587

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(methylsulfonyl)amino]-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide
CAS Number
941690-55-7
Synonyms
  • AZD 2624
  • AZD 4901
Molecular Formula
C26H25N3O3S
Formula Weight
459.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30mg/mLDMF:PBS (pH 7.2) (1:3): 0.25mg/mLDMSO: 20mg/mL
λmax
236 nm
SMILES
CS(NC1=C(C(N[C@H](C2=CC=CC=C2)CC)=O)C3=CC=CC=C3N=C1C4=CC=CC=C4)(=O)=O
InChi Code
InChI=1S/C26H25N3O3S/c1-3-21(18-12-6-4-7-13-18)28-26(30)23-20-16-10-11-17-22(20)27-24(19-14-8-5-9-15-19)25(23)29-33(2,31)32/h4-17,21,29H,3H2,1-2H3,(H,28,30)/t21-/m0/s1
InChi Key
QYTBBBAHNIWFOD-NRFANRHFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $75

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    5 mg

    $295

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    10 mg

    $442

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    50 mg

    $736

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    Product Description

    MLE-4901 is an antagonist of the neurokinin-3 (NK3) receptor.1 It inhibits human liver microsomal CYP3A4/5 with apparent IC50 values of 7.1 and 19.8 μM in midazolam 1'-hydroxylation and testosterone 6β-hydroxylation assays, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, Y., Zhou, D., Ferguson, S.S., et al. In vitro assessment of metabolic drug–drug interaction potential of AZD2624, neurokinin-3 receptor antagonist, through cytochrome P450 enzyme identification, inhibition, and induction studies. Xenobiotica 40(11), 721-729 (2010).