An NK3 receptor antagonist
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

MLE-4901

Item No. 23587

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(methylsulfonyl)amino]-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide
CAS Number
941690-55-7
Synonyms
  • AZD 2624
  • AZD 4901
Molecular Formula
C26H25N3O3S
Formula Weight
459.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
λmax
236 nm
SMILES
CS(NC1=C(C(N[C@H](C2=CC=CC=C2)CC)=O)C3=CC=CC=C3N=C1C4=CC=CC=C4)(=O)=O
InChi Code
InChI=1S/C26H25N3O3S/c1-3-21(18-12-6-4-7-13-18)28-26(30)23-20-16-10-11-17-22(20)27-24(19-14-8-5-9-15-19)25(23)29-33(2,31)32/h4-17,21,29H,3H2,1-2H3,(H,28,30)/t21-/m0/s1
InChi Key
QYTBBBAHNIWFOD-NRFANRHFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $75

    Add

    5 mg

    $295

    Add

    10 mg

    $442

    Add

    50 mg

    $736

    Add
    Product Description

    MLE-4901 is an antagonist of the neurokinin-3 (NK3) receptor.1 It inhibits human liver microsomal CYP3A4/5 with apparent IC50 values of 7.1 and 19.8 μM in midazolam 1'-hydroxylation and testosterone 6β-hydroxylation assays, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, Y., Zhou, D., Ferguson, S.S., et al. In vitro assessment of metabolic drug–drug interaction potential of AZD2624, neurokinin-3 receptor antagonist, through cytochrome P450 enzyme identification, inhibition, and induction studies. Xenobiotica 40(11), 721-729 (2010).