An antioxidant
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Graphislactone A

Item No. 23643

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,7-dihydroxy-3,9-dimethoxy-1-methyl-6H-dibenzo[b,d]pyran-6-one
CAS Number
52179-44-9
Molecular Formula
C16H14O6
Formula Weight
302.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/ml
SMILES
O=C1OC2=C(O)C(OC)=CC(C)=C2C3=C1C(O)=CC(OC)=C3
InChi Code
InChI=1S/C16H14O6/c1-7-4-11(21-3)14(18)15-12(7)9-5-8(20-2)6-10(17)13(9)16(19)22-15/h4-6,17-18H,1-3H3
InChi Key
SMKUDZVEVLDBSV-UHFFFAOYSA-N
Origin
Fungus/Cephalosporium sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $285

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    5 mg

    $927

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    Product Description

    Graphislactone A is an antioxidant produced by Cephalosporium IFB-E001 and M. olivacea.1,2 It exhibits dose-dependent scavenging activity against DPPH radicals and metal ion-dependent hydroxyl radicals in vitro.1 Graphislactone A reduces peroxidation of human LDL and slows peroxidation of linoleic acid (Item Nos. 90150 | 21909) by 4.4-fold. It also inhibits acetylcholinesterase (AChE) with an IC50 value of 27 μM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Song, Y.C., Huang, W.Y., Sun, C., et al. Characterization of graphislactone A as the antioxidant and free radical-scavenging substance from the culture of Cephalosporium sp. IFB-E001, an endophytic fungus in Trachelospermum jasminoides. Biol. Pharm. Bull. 28(3), 506-509 (2005).

    2. Hormazabal, E., Schmeda-Hirschmann, G., Astudillo, L., et al. Metabolites from Microsphaeropsis olivacea, an endophytic fungus of Pilgerodendron uviferum. Z. Naturforsch. C. 60(1-2), 11-21 (2005).