A natural steroid glycoside with diverse effects
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Ginsenoside Rf

Item No. 23667

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3β,12β,20-trihydroxydammar-24-en-6α-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside
CAS Number
52286-58-5
Molecular Formula
C42H72O14
Formula Weight
801.0
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Slightly Soluble
SMILES
O[C@H]1[C@@]2([H])[C@](CC[C@]2([H])[C@](O)(C)CC/C=C(C)/C)(C)[C@]3(C)C[C@H](O[C@]4([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O[C@]5([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@]6([H])[C@@](CC[C@H](O)C6(C)C)(C)[C@@]3([H])C1
InChi Code
InChI=1S/C42H72O14/c1-20(2)10-9-13-42(8,52)21-11-15-40(6)28(21)22(45)16-26-39(5)14-12-27(46)38(3,4)35(39)23(17-41(26,40)7)53-37-34(32(50)30(48)25(19-44)55-37)56-36-33(51)31(49)29(47)24(18-43)54-36/h10,21-37,43-52H,9,11-19H2,1-8H3/t21-,22+,23-,24+,25+,26+,27-,28-,29+,30+,31-,32-,33+,34+,35-,36-,37+,39+,40+,41+,42-/m0/s1
InChi Key
UZIOUZHBUYLDHW-XUBRWZAZSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Ginsenoside Rf is a steroid glycoside found in plants of the genus Panax that has diverse biological activities.1,2,3,4 It inhibits production of IL-1β, IL-6, TNF-α, NO, and reactive oxygen species (ROS) in human HT-29 intestinal epithelial cells and RAW 264.7 mouse macrophages in a dose-dependent manner.2 Ginsenoside Rf inhibits N-type calcium channels in rat sensory neurons (IC50 = 40 μM).1 In vivo, ginsenoside Rf has antinociceptive effects in mice in the acetic acid abdominal constriction test and in the biphasic formalin test (ED50s = 56 and 129 mg/kg, respectively), which are models of tonic pain.3 Topical administration of ginsenoside Rf (0.05% solution) reduces ear swelling by 34.8% in a mouse model of contact dermatitis.4

    WARNING This product is not for human or veterinary use.