Ginsenoside Rf

Ginsenoside Rf is a steroid glycoside found in plants of the genus Panax that has diverse biological activities.^1,2,3,4 It inhibits production of IL-1β, IL-6, TNF-α, NO, and reactive oxygen species (ROS) in human HT-29 intestinal epithelial cells and RAW 264.7 mouse macrophages in a dose-dependent manner.² Ginsenoside Rf inhibits N-type calcium channels in rat sensory neurons (IC₅₀ = 40 μM).¹ In vivo, ginsenoside Rf has antinociceptive effects in mice in the acetic acid abdominal constriction test and in the biphasic formalin test (ED₅₀s = 56 and 129 mg/kg, respectively), which are models of tonic pain.³ Topical administration of ginsenoside Rf (0.05% solution) reduces ear swelling by 34.8% in a mouse model of contact dermatitis.⁴

WARNING This product is not for human or veterinary use.

1. Nah, S.Y., Park, H.J., and McCleskey, E.W. A trace component of ginseng that inhibits Ca²⁺ channels through a pertussis toxin-sensitive G protein. Proc. Natl. Acad. Sci. USA 92(19), 8739-8743 (1995).

2. Ahn, S., Siddiqui, M.H., Aceituno, V.C., et al. Suppression of MAPKs/NF-κB activation induces intestinal anti-inflammatory action of Ginsenoside Rf in HT-29 and RAW264.7 cells. Immunol. Invest. 45(5), 439-449 (2016).

3. Mogil, J.S., Shin, Y.H., McCleskey, E.W., et al. Ginsenoside Rf, a trace component of ginseng root, produces antinociception in mice. Brain Res. 792(2), 218-228 (1998).

4. Bae, E.A., Han, M.J., Shin, Y.W., et al. Inhibitory effects of Korean red ginseng and its genuine constituents ginsenosides Rg3, Rf, and Rh2 in mouse passive cutaneous anaphylaxis reaction and contact dermatitis models. Biol. Pharm. Bull. 29(9), 1862-1867 (2006).