A steroid glycoside with diverse biological activities
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Ginsenoside Rg1

Item No. 15315

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3β,12β-dihydroxydammar-24-ene-6α,20-diyl bis-β-D-glucopyranoside
CAS Number
22427-39-0
Synonyms
  • Ginsenoside A2
  • Panaxoside A
  • Panaxoside Rg1
  • Sanchinoside C1
  • Sanchinoside Rg1
Molecular Formula
C42H72O14
Formula Weight
801.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
SMILES
O[C@H]1[C@@]2([H])[C@](CC[C@]2([H])[C@@](CC/C=C(C)/C)(C)O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)(C)[C@]4(C)C[C@H](O[C@]5([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@]6([H])[C@@](CC[C@H](O)C6(C)C)(C)[C@@]4([H])C1
InChi Code
InChI=1S/C42H72O14/c1-20(2)10-9-13-42(8,56-37-34(52)32(50)30(48)25(19-44)55-37)21-11-15-40(6)28(21)22(45)16-26-39(5)14-12-27(46)38(3,4)35(39)23(17-41(26,40)7)53-36-33(51)31(49)29(47)24(18-43)54-36/h10,21-37,43-52H,9,11-19H2,1-8H3/t21-,22+,23-,24+,25+
InChi Key
YURJSTAIMNSZAE-HHNZYBFYSA-N
Origin
Plant/Ginseng Radix et Rhizoma
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $140

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    10 mg

    $235

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    25 mg

    $487

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    Ginsenoside Rg1 is a steroid glycoside that has been found in P. ginseng and has diverse biological activities.1,2,3,4 In vivo, ginsenoside Rg1 (10, 20, and 40 mg/kg) decreases blood glucose, IL-1β, and IL-18 levels, increases insulin secretion, and inhibits hepatic and pancreatic activation of the NLRP3 inflammasome in a mouse model of diabetes induced by streptozotocin (STZ; Item No. 13104).1 It facilitates fear extinction and decreases immobility time in the tail-suspension and forced swim tests in a mouse model of single-prolonged stress-induced post-traumatic stress disorder (PTSD).2 Ginsenoside Rg1 decreases hepatic alanine transaminase (ALT) and aspartate aminotransferase (AST) levels and attenuates hepatic steatosis in a mouse model of ethanol-induced hepatitis.3 It also decreases the abundance of Bacteroidetes in the large intestine, cortical neuron apoptosis, and latency to the platform in the Morris water maze in a tree shrew model of Alzheimer’s disease induced by amyloid-β (25-35) (Aβ (25-35)).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gao, Y., Li, J., Chu, S., et al. Ginsenoside Rg1 protects mice against streptozotocin-induced type 1 diabetic by modulating the NLRP3 and Keap1/Nrf2/HO-1 pathways. Eur. J. Pharmacol. 866, 172801 (2020).

    2. Zhang, Z., Song, Z., Shen, F., et al. Ginsenoside Rg1 prevents PTSD-like behaviors in mice through promoting synaptic proteins, reducing Kir4.1 and TNF-α in the hippocampus. Mol. Neurobiol. 58(4), 1550-1563 (2021).

    3. Yang, C., He, X., Zhao, J., et al. Hepatoprotection by Ginsenoside Rg1 in alcoholic liver disease. Int. Immunopharmacol. 92, 107327 (2021).

    4. Guo, Y., Wang, L., Lu, J., et al. Ginsenoside Rg1 improves cognitive capability and affects the microbiota of large intestine of tree shrew model for Alzheimer’s disease. Mol. Med. Rep. 23(4), 291 (2021).