An antagonist of muscle-type nAChRs
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Pancuronium (bromide hydrate)

Item No. 23778

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1'-[(2β,3α,5α,16β,17β)-3,17-bis(acetyloxy)androstane-2,16-diyl]bis[1-methyl-piperidinium], dibromide, hydrate
Synonyms
  • NSC 293162
Molecular Formula
C35H60N2O4 • 2Br [XH2O]
Formula Weight
732.7
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O=C(C)O[C@H]1[C@@H]([N+]2(C)CCCCC2)C[C@@]3([H])[C@]4([H])CC[C@@]5([H])C[C@H](OC(C)=O)[C@@H]([N+]6(C)CCCCC6)C[C@]5(C)[C@@]4([H])CC[C@@]31C.[Br-].[Br-].O
InChi Code
InChI=1S/C35H60N2O4.2BrH.H2O/c1-24(38)40-32-21-26-13-14-27-28(35(26,4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36;;;/h26-33H,7-23H2,1-6H3;2*1H;1H2/q+2;;;/p-2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-;;;/m0.../s1
InChi Key
KSNRANIFOPUVTD-CVPFSWIZSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $63

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    25 mg

    $135

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    Product Description

    Pancuronium is an aminosteroid antagonist of muscle-type nicotinic acetylcholine receptors (nAChRs) with an IC50 value of 14.8 nM using patch clamp electrophysiology in BOSC23 cells expressing mouse nAChRs.1 It acts as a non-depolarizing neuromuscular blocking agent.2 Pancuronium enhances anesthesia induced by isoflurane (Item No. 23989), reducing immobilization with an ED50 value of 1.62 µg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, M., and Dilger, J.P. Site selectivity of competitive antagonists for the mouse adult muscle nicotinic acetylcholine receptor. Mol. Pharmacol. 75(1), 166-173 (2009).

    2. Buckett, W.R., Marjoribanks, C.E., Marwick, F.A., et al. The pharmacology of pancuronium bromide (Org.NA97), a new potent steroidal neuromuscular blocking agent. Br. J. Pharmacol. Chemother. 32(3), 671-682 (1968).

    3. Miyazaki, Y., Sunaga, H., Hobo, S., et al. Pancuronium enhances isoflurane anesthesia in rats via inhibition of cerebral nicotinic acetylcholine receptors. J. Anesth. 30(4), 671-676 (2016).