A reduced folic acid
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L-Folinic Acid (calcium salt hydrate)

Item No. 23833

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[[[(6S)-2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-L-glutamic acid, monocalcium salt, hydrate
Synonyms
  • L-Folinate
  • 5-Formyltetrahydrofolate
Molecular Formula
C20H21N7O7 • Ca [XH2O]
Formula Weight
471.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Water: 0.3 mg/ml
λmax
221, 287 nm
SMILES
NC(NC1=C2N(C=O)[C@@H](CNC3=CC=C(C(N[C@H](C([O-])=O)CCC([O-])=O)=O)C=C3)CN1)=NC2=O.[Ca+2].O
InChi Code
InChI=1S/C20H23N7O7.Ca.H2O/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);;1H2/q;+2;/p-2/t12-,13-;;/m0../s1
InChi Key
ANIWFDFELBSPJN-NJHZPMQHSA-L
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $103

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    500 mg

    $194

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    1 g

    $363

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    Cayman Chemical
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    Product Description

    L-Folinic acid is a reduced folic acid and isomer of DL-folinic acid (Item No. 20383).1 Formulations containing DL-folinic acid, a racemic mixture of D-folinic acid and L-folinic acid, that have been used to prevent toxicity following therapy with high-dose methotrexate, to enhance the antitumor activity of 5-fluorouracil, and as a folate supplement.2,3 Clinical studies demonstrate that formulations containing L-folinic acid have similar efficacy and tolerability as those contianing DL-folinic acid and have been used interchangeably for modification of antitumor activity of 5-fluorouracil, while D-folinic acid is inactive.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kovoor, P.A., Karim, S.M., and Marshall, J.L. Is levoleucovorin an alternative to racemic leucovorin? A literature review. Clin. Colorectal Cancer 8(4), 200-206 (2009).

    2. Danenberg, P.V., Gustavsson, B., Johnston, P., et al. Folates as adjuvants to anticancer agents: Chemical rationale and mechanism of action. Crit. Rev. Oncol. Hematol. 106, 118-131 (2016).

    3. Frye, R.E., Rossignol, D., Casanova, M.F., et al. A review of traditional and novel treatments for seizures in autism spectrum disorder: Findings from a systematic review and expert panel. Front. Public Health 1, 31 (2013).