A formyl donor and cofactor
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10-Formyltetrahydrofolate (sodium salt) (technical grade)

Item No. 35763

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]formylamino]benzoyl]-L-glutamic acid, disodium salt
CAS Number
914800-65-0
Synonyms
  • 10-CHO-FH4
  • 10-CHO-THF
  • N10-Formyltetrahydrofolate
  • 10-formyl H4PteGlu
  • 10-fTHF
Molecular Formula
C20H21N7O7 • 2Na
Formula Weight
517.4
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: slightly solubleWater: slightly soluble
SMILES
O=C1C2=C(NC(N)=N1)NCC(N2)CN(C3=CC=C(C=C3)C(N[C@H](C([O-])=O)CCC([O-])=O)=O)C=O.[Na+].[Na+]
InChi Code
InChI=1S/C20H23N7O7.2Na/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30;;/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32);;/q;2*+1/p-2/t11?,13-;;/m0../s1
InChi Key
YAAHOQFUMOTHOP-UAAMANLASA-L
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    1 mg

    $247

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    Product Description

    10-Formyltetrahydrofolate is a formyl donor and cofactor, as well as a metabolite of 5,10-methylenetetrahydrofolic acid (folitixorin; Item No. 33967).1 It is formed from 5,10-methylenetetrahydrofolic acid by methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) in the cytosol and MTHFD2 and MTHFD2L in the mitochondria. 10-Formyltetrahydrofolate provides the formyl group for conjugation to methionine-tRNA, which is required for mitochondrial protein translation initiation, and is also involved in purine biosynthesis.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, A.M., and Ye, J. Reprogramming of serine, glycine and one-carbon metabolism in cancer. Biochim. Biophys. Acta Mol. Basis Dis. 1866(10), 165841 (2020).

    2. Minton, D.R., Nam, M., McLaughlin, D.J., et al. Serine catabolism by SHMT2 is required for proper mitochondrial translation initiation and maintenance of formylmethionyl-tRNAs. Mol. Cell 69(4), 610-621 (2018).

    3. Berg, J.M., Tymoczko, J.L., and Stryer, L. Nucleotide biosynthesis. Biochemistry (2002).