A reduced folic acid
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DL-Folinic Acid (calcium salt)

Item No. 20383

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid, monocalcium salt
CAS Number
1492-18-8
Synonyms
  • DL-Folinate
  • NSC 3590
  • 5-Formyltetrahydrofolate
Molecular Formula
C20H21N7O7 • Ca
Formula Weight
511.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Water: 0.3 mg/ml
λmax
220, 287 nm
SMILES
O=CN1C(CNC2=CC=C(C(N[C@H](C([O-])=O)CCC([O-])=O)=O)C=C2)CNC3=C1C(N=C(N)N3)=O.[Ca+2]
InChi Code
InChI=1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1
InChi Key
KVUAALJSMIVURS-ZEDZUCNESA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $63

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    250 mg

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    500 mg

    $229

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    Cayman Chemical
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    Product Description

    DL-Folinic acid is a formylated form of tetrahydrofolic acid, the reduced form of folic acid, a B vitamin. DL-Folinic acid is used to prevent toxicity following therapy with high-dose methotrexate (Item No. 13960), to enhance the antitumor activity of 5-fluorouracil (Item No. 14416), and as a folate supplement.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Danenberg, P.V., Gustavsson, B., Johnston, P., et al. Folates as adjuvants to anticancer agents: Chemical rationale and mechanism of action. Crit. Rev. Oncol. Hematol. 106, 118-131 (2016).

    2. Frye, R.E., Rossignol, D., Casanova, M.F., et al. A review of traditional and novel treatments for seizures in autism spectrum disorder: Findings from a systematic review and expert panel. Front. Public Health 1, 31 (2013).