A triazole antifungal agent
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Labeled Version(s)
33638Efinaconazole-d4
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Efinaconazole

Item No. 23839

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
αR-(2,4-difluorophenyl)-βR-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol
CAS Number
164650-44-6
Synonyms
  • KP-103
Molecular Formula
C18H22F2N4O
Formula Weight
348.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: slightly solubleDMSO: >14 mg/mlMethanol: slightly soluble
λmax
262 nm
SMILES
FC(C=C1F)=CC=C1[C@](CN2N=CN=C2)(O)[C@@H](C)N3CCC(CC3)=C
InChi Code
InChI=1S/C18H22F2N4O/c1-13-5-7-23(8-6-13)14(2)18(25,10-24-12-21-11-22-24)16-4-3-15(19)9-17(16)20/h3-4,9,11-12,14,25H,1,5-8,10H2,2H3/t14-,18-/m1/s1
InChi Key
NFEZZTICAUWDHU-RDTXWAMCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Product Description

    Efinaconazole is a broad-spectrum triazole antifungal agent with activity against Acremonium, Aspergillus, Candida, Cryptococcus, Epidermophyton, Fusarium, Microsporum, Paecilomyces, Pseudallescheria, Scopulariopsis, Trichophyton, and Trichosporon.1 It inhibits the growth of T. rubrum and T. mentagrophytes clinical isolates with MIC values ranging from ≤2.0 to 60 ng/ml and of C. albicans isolates with MIC values ranging from ≤0.5 to >250 ng/ml. Efinaconazole inhibits sterol 14α-demethylase, which arrests ergosterol (Item No. 19850) biosynthesis at the fungal membrane.2 It inhibits ergosterol biosynthesis in T. mentagrophytes and C. albicans with IC50 values of 7.0 and 0.40 ng/ml, respectfully. Topical formulations containing efinaconazole have been used for the treatment of onychomycosis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jo Siu, W.J., Tatsumi, Y., Senda, H., et al. Comparison of in vitro antifungal activities of efinaconazole and currently available antifungal agents against a variety of pathogenic fungi associated with onychomycosis. Antimicrob. Agents Chemother. 57(4), 1610-1616 (2013).

    2. Tatsumi, Y., Nagashima, M., Shibanushi, T., et al. Mechanism of action of efinaconazole, a novel triazole antifungal agent. Antimicrob. Agents Chemother. 57(5), 2405-2409 (2013).