An internal standard for the quantification of efinaconazole
Related Products
Unlabeled Version(s)
23839Efinaconazole
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Efinaconazole-d4

Item No. 33638

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidin-1-yl-2,2,6,6-d4)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
Molecular Formula
C18H18D4F2N4O
Formula Weight
352.4
Purity
≥99% deuterated forms (d1-d4)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: solubleMethanol: soluble
SMILES
C=C1CC([2H])([2H])N([C@@H]([C@](CN2C=NC=N2)(C3=CC=C(F)C=C3F)O)C)C([2H])([2H])C1
InChi Code
InChI=1S/C18H22F2N4O/c1-13-5-7-23(8-6-13)14(2)18(25,10-24-12-21-11-22-24)16-4-3-15(19)9-17(16)20/h3-4,9,11-12,14,25H,1,5-8,10H2,2H3/t14-,18-/m1/s1/i7D2,8D2
InChi Key
NFEZZTICAUWDHU-INFILRCQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $163

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    1 mg

    $311

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    5 mg

    $1,059

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    Cayman Chemical
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    Product Description

    Efinaconazole-d4 is intended for use as an internal standard for the quantification of efinaconazole (Item No. 23839) by GC- or LC-MS. Efinaconazole is a broad-spectrum triazole antifungal agent with activity against Acremonium, Aspergillus, Candida, Cryptococcus, Epidermophyton, Fusarium, Microsporum, Paecilomyces, Pseudallescheria, Scopulariopsis, Trichophyton, and Trichosporon.1 It inhibits the growth of T. rubrum and T. mentagrophytes clinical isolates with MIC values ranging from ≤2.0 to 60 ng/ml and of C. albicans isolates with MIC values ranging from ≤0.5 to >250 ng/ml. Efinaconazole inhibits sterol 14α-demethylase, which arrests ergosterol (Item No. 19850) biosynthesis at the fungal membrane.2 It inhibits ergosterol biosynthesis in T. mentagrophytes and C. albicans with IC50 values of 7.0 and 0.40 ng/ml, respectfully. Topical formulations containing efinaconazole have been used for the treatment of onychomycosis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jo Siu, W.J., Tatsumi, Y., Senda, H., et al. Comparison of in vitro antifungal activities of efinaconazole and currently available antifungal agents against a variety of pathogenic fungi associated with onychomycosis. Antimicrob. Agents Chemother. 57(4), 1610-1616 (2013).

    2. Tatsumi, Y., Nagashima, M., Shibanushi, T., et al. Mechanism of action of efinaconazole, a novel triazole antifungal agent. Antimicrob. Agents Chemother. 57(5), 2405-2409 (2013).