A dopamine D2 receptor agonist
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Active Metabolite(s)
34156N-Despropyl Ropinirole
Labeled Version(s)
31689Ropinirole-d7 (hydrochloride)
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Ropinirole (hydrochloride)

Item No. 23871

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-(dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one, monohydrochloride
CAS Number
91374-20-8
Synonyms
  • SKF 101468A
Molecular Formula
C16H24N2O • HCl
Formula Weight
296.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
250 nm
SMILES
O=C1NC2=CC=CC(CCN(CCC)CCC)=C2C1.Cl
InChi Code
InChI=1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H
InChi Key
XDXHAEQXIBQUEZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    25 mg

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    50 mg

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    Product Description

    Ropinirole is a potent dopamine D2 receptor agonist (Ki = 29 nM in a radioligand binding assay).1 It is selective for D2 over D1 dopamine receptors (Ki = >100,000 nM) as well as a panel of adrenergic, serotonin, benzodiazepine, and GABA receptors (IC50s = >9,000 nM). Ropinirole reduces spontaneous locomotor activity in mice at doses less than 50 mg/kg but increases it at a dose of 100 mg/kg. It also induces contralateral asymmetry in an open field test in 6-OHDA-lesioned mice. Ropinirole (0.01-1 mg/kg) reverses locomotor deficits and restores interest in novel stimuli in a marmoset model of Parkinson's disease induced by MPTP. Formulations containing ropinirole have been used for the treatment of Parkinson's disease motor dysfunction.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Eden, R.J., Costall, B., Domeney, A.M., et al. Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist. Pharmacol. Biochem. Behav. 38(1), 147-154 (1991).