An organophosphate pesticide
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Labeled Version(s)
39260Dimethoate-d6
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Dimethoate

Item No. 24246

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
phosphorodithioic acid, O,O-dimethyl S-[2-(methylamino)-2-oxoethyl] ester
CAS Number
60-51-5
Synonyms
  • CL 12,880
  • ENT 24,650
Molecular Formula
C5H12NO3PS2
Formula Weight
229.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly SolubleDMSO: Slightly Soluble
SMILES
CNC(CSP(OC)(OC)=S)=O
InChi Code
InChI=1S/C5H12NO3PS2/c1-6-5(7)4-12-10(11,8-2)9-3/h4H2,1-3H3,(H,6,7)
InChi Key
MCWXGJITAZMZEV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $36

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    100 mg

    $68

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    Cayman Chemical
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    Product Description

    Dimethoate is an organophosphate pesticide.1 It is acaricidal against Kanzawa spider mites (LC50 = 7 ppm in an aqueous suspension) and inhibits purified Kanzawa spider mite acetylcholinesterase (AChE; IC50 = 3.3-5.2 nM). Dimethoate (50-200 μM) reduces motility and viability and induces abnormal morphology of rat sperm.2 It also increases production of malondialdehyde (MDA) and reduces superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (Gpx) activities in rat epididymal sperm. In vivo, dimethoate (28 mg/kg per day) decreases sperm count, motility, and viability and increases the percentage of morphologically abnormal sperm in rats.3 Dimethoate also induces formation of carcinomas in the adrenal, thyroid, and pituitary glands of male and female rats as well as testicular atrophy, chronic renal disease, polyarteritis, and parathyroid hyperplasia in male rats.4 Formulations containing dimethoate have been used in the control of insects in agriculture, as well as in aquatic and residential areas.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kuwahara, M. Insensitivity of the acetylcholinesterase from the organophosphate-resistant Kanzawa spider mite, Tetranychus kanzawa Kishida (Acarina: Tetranychidae) to organophosphorus and carbamate insecticides. Appl. Ent. Zool. 17(4), 486-493 (1982).

    2. Ben Abdallah, F., Fetoui, H., Zribi, N., et al. Antioxidant supplementations in vitro improve rat sperm parameters and enhance antioxidant enzyme activities against dimethoate-induced sperm damages. Andrologia 44(Suppl 1), 272-279 (2012).

    3. Abdallah, F.B., Slima, A.B., Dammak, I., et al. Comparative effects of dimethoate and deltamethrin on reproductive system in male mice. Andrologia 42(3), 182-186 (2010).

    4. Reuber, M.D. Carcinogenicity of dimethoate. Environ. Res. 34(2), 193-211 (1984).