An internal standard for the quantification of dimethoate
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Unlabeled Version(s)
24246Dimethoate
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Dimethoate-d6

Item No. 39260

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
phosphorodithioic acid, O,O-di(methyl-d3) S-[2-(methylamino)-2-oxoethyl] ester
CAS Number
1219794-81-6
Molecular Formula
C5H6D6NO3PS2
Formula Weight
235.3
Purity
≥99% deuterated forms (d1-d6)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleChloroform: Soluble: ≥ 10 mg/mlDMSO: SolubleDMSO: Soluble: ≥ 10 mg/mlMethanol: Sparingly soluble: 1-10 mg/ml
SMILES
CNC(CSP(OC([2H])([2H])[2H])(OC([2H])([2H])[2H])=S)=O
InChi Code
InChI=1S/C5H12NO3PS2/c1-6-5(7)4-12-10(11,8-2)9-3/h4H2,1-3H3,(H,6,7)/i2D3,3D3
InChi Key
MCWXGJITAZMZEV-XERRXZQWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Dimethoate-d6 is intended for use as an internal standard for the quantification of dimethoate (Item No. 24246) by GC- or LC-MS. Dimethoate is an organophosphate pesticide.1 It is acaricidal against Kanzawa spider mites (LC50 = 7 ppm in an aqueous suspension). Dimethoate (50-200 μM) reduces motility and viability and induces abnormal morphology of rat sperm.2 It also increases production of malondialdehyde (MDA) and reduces superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) activities in rat epididymal sperm. In vivo, dimethoate (28 mg/kg per day) decreases sperm count, motility, and viability and increases the percentage of morphologically abnormal sperm in rats.3 Dimethoate also induces formation of carcinomas in the adrenal, thyroid, and pituitary glands of male and female rats as well as testicular atrophy, chronic renal disease, polyarteritis, and parathyroid hyperplasia in male rats.4 Formulations containing dimethoate have been used as insecticides and miticides in aquatic food production and agriculture.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kuwahara, M. Insensitivity of the acetylcholinesterase from the organophosphate-resistant Kanzawa spider mite, Tetranychus kanzawa Kishida (Acarina: Tetranychidae) to organophosphorus and carbamate insecticides. Appl. Ent. Zool. 17(4), 486-493 (1982).

    2. Ben Abdallah, F., Fetoui, H., Zribi, N., et al. Antioxidant supplementations in vitro improve rat sperm parameters and enhance antioxidant enzyme activities against dimethoate-induced sperm damages. Andrologia 44(Suppl 1), 272-279 (2012).

    3. Abdallah, F.B., Slima, A.B., Dammak, I., et al. Comparative effects of dimethoate and deltamethrin on reproductive system in male mice. Andrologia 42(3), 182-186 (2010).

    4. Reuber, M.D. Carcinogenicity of dimethoate. Environ. Res. 34(2), 193-211 (1984).