A potent inhibitor of acid ceramidase
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ARN14988

Item No. 24284

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-chloro-3-[(hexylamino)carbonyl]-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinecarboxylic acid, 2-methylpropyl ester
CAS Number
1502027-70-4
Molecular Formula
C16H24ClN3O5
Formula Weight
373.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.33 mg/mlEthanol: Slightly soluble
λmax
216, 269 nm
SMILES
O=C(OCC(C)C)N(C(C(Cl)=CN1C(NCCCCCC)=O)=O)C1=O
InChi Code
InChI=1S/C16H24ClN3O5/c1-4-5-6-7-8-18-14(22)19-9-12(17)13(21)20(15(19)23)16(24)25-10-11(2)3/h9,11H,4-8,10H2,1-3H3,(H,18,22)
InChi Key
PBVLSEVDIRSYGE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $213

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    10 mg

    $376

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    25 mg

    $820

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    Product Description

    ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme).1 It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide (Item No. 24369) and C16 ceramide (Item No. 10681) in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells (EC50s = 41.8 and 67.7 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Realini, N., Palese, F., Pizzirani, D., et al. Acid ceramidase in melanoma: Expression, localization, and effects of pharmacological inhibition. The Journal of Biological Chemisty 291(5), 2422-2434 (2016).