A neuropeptide agonist of NMU1 and NMU2 receptors
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Neuromedin S (rat) (trifluoroacetate salt)

Item No. 24547

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-leucyl-L-prolyl-L-arginyl-L-leucyl-L-leucyl-L-histidyl-L-threonyl-L-α-aspartyl-L-seryl-L-arginyl-L-methionyl-L-alanyl-L-threonyl-L-isoleucyl-L-α-aspartyl-L-phenylalanyl-L-prolyl-L-lysyl-L-lysyl-L-α-aspartyl-L-prolyl-L-threonyl-L-threonyl-L-seryl-L-leucylglycyl-L-arginyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-arginyl-L-prolyl-L-arginyl-L-aspartamide, trifluoroacetate salt
Synonyms
  • NMS
Molecular Formula
C193H307N57O49S • XCF3COOH
Formula Weight
4241.9
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC([C@H](CC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@H]1CCCN1C([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](NC([C@@H]2CCCN2C([C@H](CCCNC(N)=N)NC(CNC([C@H](CC(C)C)NC([C@H](CO)NC([C@@]([C@@H](C)O)([H])NC([C@@]([C@@H](C)O)([H])NC([C@@H]3CCCN3C([C@@H](NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@@H]4CCCN4C([C@@H](NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H]5CCCN5C([C@H](CC(C)C)N[H])=O)=O)=O)=O)=O)CC6=CN=CN6)=O)=O)CC(O)=O)=O)=O)=O)CCSC)=O)C)=O)=O)=O)CC(O)=O)=O)CC7=CC=CC=C7)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC8=CC=CC=C8)=O)CC9=CC=CC=C9)=O)=O)CC%10=CC=CC=C%10)=O)=O)=O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C193H307N57O49S.C2HF3O2/c1-19-104(12)149(241-182(293)152(108(16)255)242-155(266)105(13)217-157(268)121(66-79-300-18)221-159(270)118(56-36-69-210-189(199)200)220-172(283)137(96-251)239-170(281)134(92-147(261)262)236-180(291)150(106(14)253)243-171(282)132(89-114-94-209-98-216-114)233-165(276)128(84-103(10)11)229-163(274)126(82-101(6)7)228-161(272)120(58-38-71-212-191(203)204)224-174(285)139-61-41-74-246(139)184(295)115(196)80-99(2)3)179(290)235-133(91-146(259)260)169(280)237-135(88-113-52-30-23-31-53-113)187(298)249-77-44-63-141(249)176(287)222-117(55-33-35-68-195)158(269)219-116(54-32-34-67-194)162(273)238-136(93-148(263)264)188(299)250-78-45-65-143(250)178(289)244-153(109(17)256)183(294)245-151(107(15)254)181(292)240-138(97-252)173(284)227-125(81-100(4)5)156(267)215-95-145(258)218-122(59-39-72-213-192(205)206)185(296)247-75-43-64-142(247)177(288)234-131(87-112-50-28-22-29-51-112)168(279)232-130(86-111-48-26-21-27-49-111)167(278)230-127(83-102(8)9)164(275)231-129(85-110-46-24-20-25-47-110)166(277)225-123(60-40-73-214-193(207)208)186(297)248-76-42-62-140(248)175(286)223-119(57-37-70-211-190(201)202)160(271)226-124(154(198)265)90-144(197)257;3-2(4,5)1(6)7/h20-31,46-53,94,98-109,115-143,149-153,251-256H,19,32-45,54-93,95-97,194-196H2,1-18H3,(H2,197,257)(H2,198,265)(H,209,216)(H,215,267)(H,217,268)(H,218,258)(H,219,269)(H,220,283)(H,221,270)(H,222,287)(H,223,286)(H,224,285)(H,225,277)(H,226,271)(H,227,284)(H,228,272)(H,229,274)(H,230,278)(H,231,275)(H,232,279)(H,233,276)(H,234,288)(H,235,290)(H,236,291)(H,237,280)(H,238,273)(H,239,281)(H,240,292)(H,241,293)(H,242,266)(H,243,282)(H,244,289)(H,245,294)(H,259,260)(H,261,262)(H,263,264)(H4,199,200,210)(H4,201,202,211)(H4,203,204,212)(H4,205,206,213)(H4,207,208,214);(H,6,7)/t104-,105-,106+,107+,108+,109+,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,149-,150-,151-,152-,153-;/m0./s1
InChi Key
BVDHSKWINGQBGF-PRNNQPPSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $290

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    Product Description

    Neuromedin S is a neuropeptide agonist of the neuromedin U (NMU) receptors that increases calcium concentrations in CHO cells overexpressing NMU1 and NMU2 (EC50s = 65 and 91 pM, respectively).1 Neuromedin S (1 nmol, i.c.v.) induces phase shifts in the circadian rhythm of locomotor activity in rats without altering the circadian period length.1 It also suppresses food and water intake in a dose-dependent manner when administered to rats during the dark period at doses ranging from 0.1 to 5 nmol.2 Co-administration of neuromedin S (1 nmol, i.c.v.) inhibits the ability of neuropeptide Y (Item Nos. 15071 | 24716), ghrelin (Item No. 24458), and agouti-related protein (ARP) to stimulate food intake in rats by greater than 50%. Neuromedin S (0.2 nmol, i.c.v.) increases vasopressin levels in rat plasma within five minutes to levels five times greater than a saline control and decreases urinary volume by 25% during the dark period.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mori, K., Miyazato, M., Ida, T., et al. Identification of neuromedin S and its possible role in the mammalian circadian oscillator system. EMBO J. 24(2), 325-335 (2005).

    2. Ida, T., Mori, K., Miyazato, M., et al. Neuromedin s is a novel anorexigenic hormone. Endocrinology 146(10), 4217-4223 (2005).

    3. Sakamoto, T., Mori, K., Nakahara, k., et al. Neuromedin S exerts an antidiuretic action in rats. Biochem. Bioph. Res. Commun. 361(2), 457-461 (2007).