A neuropeptide with diverse biological activities
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β-CGRP (human) (trifluoroacetate salt)

Item No. 24725

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-L-asparagine-22-L-methionine-25-L-serine-α-calcitonin gene-related peptide (human), trifluoroacetate salt
Synonyms
  • Calcitonin Gene-Related Peptide-2 (human)
  • β-Calcitonin Gene-Related Peptide (human)
  • CGRP-2 (human)
Molecular Formula
C162H267N51O48S3 • XCF3COOH
Formula Weight
3793.4
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@H](CO)NC(CNC([C@H](C(C)C)NC([C@H](CC(N)=O)NC([C@@]([C@@H](C)O)([H])NC([C@@H]1CCCN1C([C@H](C(C)C)NC([C@@H](NC([C@H](CC(N)=O)NC([C@H](CO)NC([C@H](CCCCN)NC([C@H](C(C)C)NC([C@@H](NC(CNC(CNC([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(CNC([C@@H](NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@H](C(C)C)NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@H](CC(N)=O)N2)=O)=O)C)=O)=O)CSSC[C@H](NC([C@@H](N[H])C)=O)C2=O)=O)=O)=O)CC3=CN=CN3)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCSC)=O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)CC5=CC=CC=C5)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C162H267N51O48S3.C2HF3O2/c1-74(2)53-98(186-118(227)65-178-130(231)82(16)182-139(240)99(54-75(3)4)193-135(236)94(43-34-49-175-161(170)171)188-142(243)102(58-91-62-174-73-181-91)198-158(259)127(88(22)221)212-155(256)122(79(11)12)207-151(252)111-72-264-263-71-110(203-129(230)81(15)165)150(251)197-104(60-114(167)223)146(247)210-124(85(19)218)156(257)184-84(18)132(233)209-125(86(20)219)159(260)204-111)140(241)194-100(55-76(5)6)141(242)202-108(69-216)148(249)190-95(44-35-50-176-162(172)173)137(238)200-106(67-214)133(234)179-63-116(225)177-64-117(226)185-96(46-52-262-23)138(239)206-121(78(9)10)154(255)191-93(42-31-33-48-164)136(237)201-109(70-217)149(250)196-103(59-113(166)222)143(244)195-101(57-90-39-28-25-29-40-90)144(245)208-123(80(13)14)160(261)213-51-36-45-112(213)152(253)211-126(87(21)220)157(258)199-105(61-115(168)224)145(246)205-120(77(7)8)153(254)180-66-119(228)187-107(68-215)147(248)189-92(41-30-32-47-163)134(235)183-83(17)131(232)192-97(128(169)229)56-89-37-26-24-27-38-89;3-2(4,5)1(6)7/h24-29,37-40,62,73-88,92-112,120-127,214-221H,30-36,41-61,63-72,163-165H2,1-23H3,(H2,166,222)(H2,167,223)(H2,168,224)(H2,169,229)(H,174,181)(H,177,225)(H,178,231)(H,179,234)(H,180,254)(H,182,240)(H,183,235)(H,184,257)(H,185,226)(H,186,227)(H,187,228)(H,188,243)(H,189,248)(H,190,249)(H,191,255)(H,192,232)(H,193,236)(H,194,241)(H,195,244)(H,196,250)(H,197,251)(H,198,259)(H,199,258)(H,200,238)(H,201,237)(H,202,242)(H,203,230)(H,204,260)(H,205,246)(H,206,239)(H,207,252)(H,208,245)(H,209,233)(H,210,247)(H,211,253)(H,212,256)(H4,170,171,175)(H4,172,173,176);(H,6,7)/t81-,82-,83-,84-,85+,86+,87+,88+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,120-,121-,122-,123-,124-,125-,126-,127-;/m0./s1
InChi Key
GQLXFRMJBCXCCG-RYZBVDOXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    1 mg

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    Product Description

    β-Calcitonin gene-related peptide (β-CGRP) is a neuropeptide with roles in vasodilation, cardiovascular regulation, and inflammation.1 It belongs to the calcitonin family of peptides, which also includes α-CGRP (Item Nos. 24405 | 24728), amylin (Item No. 24274), calcitonin (Item Nos. 24409 | 24410), and adrenomedullin.2 β-CGRP binds selectively to a heteromeric complex of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1; IC50 = 0.01 nM) over a complex of CLCR and RAMP2 (IC50 = 300 nM).3 It binds to rat brain and spleen membrane preparations (IC50s = 1.1 and 1 nM, respectively) and relaxes human cerebral and middle meningeal arterial segments precontracted with prostaglandin F2α (PGF2α; Item No. 16010; IC50s = 0.38 and 4.9 nM, respectively).4,5 In vivo, β-CGRP induces a 50% increase in diameter of arterioles precontracted with human endothelin-1 (ET-1; Item No. 24127) in hamster cheek pouch at a concentration of 15.8 pM.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Russell, F.A., King, R., Smillie, S.-J., et al. Calcitonin gene-related peptide: Physiology and pathophysiology. Physiol. Rev. 94(4), 1099-1142 (2014).

    2. Wimalawansa, S.J. Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: A peptide superfamily. Crit. Rev. Neurobiol. 11(2-3), 167-239 (1997).

    3. McLatchie, L.M., Fraser, N.J., Main, M.J., et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 393(6683), 333-339 (1998).

    4. Dennis, T., Fournier, A., St. Pierre, S., et al. Structure-activity profile of calcitonin gene-related peptide in peripheral and brain tissues. Evidence for receptor multiplicity. J. Pharmacol. Exp. Ther. 251(2), 718-725 (1989).

    5. Jansen-Olesen, I., Jørgensen, L., Engel, U., et al. In-depth characterization of CGRP receptors in human intracranial arteries. Eur. J. Pharmacol. 481(2-3), 207-216 (2003).

    6. Hall, J.M., and Brain, S.D. Interaction of amylin with calcitonin gene-related peptide receptors in the microvasculature of the hamster cheek pouch in vivo. Br. J. Pharmacol. 126(1), 280-284 (1999).