A neuropeptide hormone
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Urocortin (rat) (trifluoroacetate salt)

Item No. 24745

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-aspartyl-L-α-aspartyl-L-prolyl-L-prolyl-L-leucyl-L-seryl-L-isoleucyl-L-α-aspartyl-L-leucyl-L-threonyl-L-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-threonyl-L-leucyl-L-leucyl-L-α-glutamyl-L-leucyl-L-alanyl-L-arginyl-L-threonyl-L-glutaminyl-L-seryl-L-glutaminyl-L-arginyl-L-α-glutamyl-L-arginyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-isoleucyl-L-isoleucyl-L-phenylalanyl-L-α-aspartyl-L-seryl-L-valinamide, trifluoroacetate salt
CAS Number
171543-83-2
Molecular Formula
C206H338N62O64 • XCF3COOH
Formula Weight
4707.3
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
NC([C@H](C(C)C)NC([C@H](CO)NC([C@@H](NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC([C@@]([C@H](CC)C)([H])NC([C@H](CCCNC(N)=N)NC([C@H](CC(N)=O)NC([C@H](CCC(N)=O)NC([C@H](CCC(O)=O)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CO)NC([C@H](CCC(N)=O)NC([C@@]([C@@H](C)O)([H])NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@@]([C@@H](C)O)([H])NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@H](CC(C)C)NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC([C@H](CO)NC([C@H](CC(C)C)NC([C@@H]1CCCN1C([C@@H]2CCCN2C([C@@H](NC([C@@H](N[H])CC(O)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)CC3=CC=CC=C3)=O)CC4=CN=CN4)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)CC5=CC=CC=C5)=O)CC(O)=O)=O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C206H338N62O64.C2HF3O2/c1-28-102(20)156(262-192(323)141(92-271)258-182(313)129(78-98(12)13)251-193(324)142-53-42-72-267(142)201(332)143-54-43-73-268(143)200(331)138(88-154(291)292)256-165(296)113(207)84-151(285)286)194(325)255-137(87-153(289)290)187(318)247-131(80-100(16)17)189(320)266-161(109(27)274)199(330)254-133(82-111-46-35-32-36-47-111)183(314)248-134(83-112-89-223-93-229-112)185(316)246-128(77-97(10)11)180(311)244-126(75-95(6)7)178(309)236-118(52-41-71-228-206(221)222)176(307)265-160(108(26)273)198(329)252-130(79-99(14)15)181(312)245-127(76-96(8)9)179(310)240-124(60-66-150(283)284)172(303)243-125(74-94(4)5)177(308)231-106(24)163(294)232-116(50-39-69-226-204(217)218)175(306)264-159(107(25)272)197(328)242-121(57-63-146(210)277)173(304)257-139(90-269)190(321)241-119(55-61-144(208)275)168(299)235-115(49-38-68-225-203(215)216)167(298)239-123(59-65-149(281)282)170(301)234-114(48-37-67-224-202(213)214)166(297)230-105(23)164(295)233-122(58-64-148(279)280)169(300)238-120(56-62-145(209)276)171(302)249-135(85-147(211)278)186(317)237-117(51-40-70-227-205(219)220)174(305)261-158(104(22)30-3)196(327)263-157(103(21)29-2)195(326)253-132(81-110-44-33-31-34-45-110)184(315)250-136(86-152(287)288)188(319)259-140(91-270)191(322)260-155(101(18)19)162(212)293;3-2(4,5)1(6)7/h31-36,44-47,89,93-109,113-143,155-161,269-274H,28-30,37-43,48-88,90-92,207H2,1-27H3,(H2,208,275)(H2,209,276)(H2,210,277)(H2,211,278)(H2,212,293)(H,223,229)(H,230,297)(H,231,308)(H,232,294)(H,233,295)(H,234,301)(H,235,299)(H,236,309)(H,237,317)(H,238,300)(H,239,298)(H,240,310)(H,241,321)(H,242,328)(H,243,303)(H,244,311)(H,245,312)(H,246,316)(H,247,318)(H,248,314)(H,249,302)(H,250,315)(H,251,324)(H,252,329)(H,253,326)(H,254,330)(H,255,325)(H,256,296)(H,257,304)(H,258,313)(H,259,319)(H,260,322)(H,261,305)(H,262,323)(H,263,327)(H,264,306)(H,265,307)(H,266,320)(H,279,280)(H,281,282)(H,283,284)(H,285,286)(H,287,288)(H,289,290)(H,291,292)(H4,213,214,224)(H4,215,216,225)(H4,217,218,226)(H4,219,220,227)(H4,221,2
InChi Key
BTOGVDGOXGIAEB-FJAJBMFWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Urocortin is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF, urocortin II (Item Nos. 24746 | 24747), urocortin III (Item Nos. 24748 | 24749 | 24750), frog sauvagine, and piscine urotensin I.1 Rat urocortin shares 63 and 45% sequence identity to urotensin and CRF, respectively. It is primarilly expressed in the Edinger-Westphal nucleus and lateral superior olive regions in the adult rat brain but can also be expressed in the periphery. Urocortin binds to type 1 and 2 CRF receptors as well as CRF binding protein (CRF-BP) with Ki values of 0.16, 0.41, and 0.10 nM for CRF1, CRF2β, and CRF-BP, respectively. It induces cAMP production in CHO cells expressing CRF1 and CRF2β (EC50s = 0.8 and 0.18 nM, respectively) and secretion of adrenocorticotropic hormone (ACTH) by rat anterior pituitary cells (EC50 = 0.006 nM). In vivo, urocortin (0.94-18.85 μg/kg) decreases mean arterial pressure and increases plasma levels of ACTH in rats. Urocortin inhibits gastric emptying of a solid meal in mice and rats and inhibits gastric motility and transit induced by vagal stimulation in rats.2 Levels of urocortin mRNA increase in testis in response to ischemia-reperfusion injury in a rat model of testicular torsion.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vaughan, J., Donaldson, C., Bittencourt, J., et al. Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature 378(6554), 287-292 (1995).

    2. Martinez, V., Wang, L., Million, M., et al. Urocortins and the regulation of gastrointestinal motor function and visceral pain. Peptides 25(10), 1733-1744 (2004).

    3. Sumii, K., Miyake, H., Enatsu, N., et al. Characterization of urocortin as an anti-apoptotic protein in experimental ischemia-reperfusion model of the rat testis. Biochem. Biophys. Res. Commun. 479(2), 387-392 (2016).