A neuropeptide hormone
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Urocortin II (mouse) (trifluoroacetate salt)

Item No. 24747

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-valyl-L-isoleucyl-L-leucyl-L-seryl-L-leucyl-L-α-aspartyl-L-valyl-L-prolyl-L-isoleucylglycyl-L-leucyl-L-leucyl-L-arginyl-L-isoleucyl-L-leucyl-L-leucyl-L-α-glutamyl-L-glutaminyl-L-alanyl-L-arginyl-L-tyrosyl-L-lysyl-L-alanyl-L-alanyl-L-arginyl-L-asparaginyl-L-glutaminyl-L-alanyl-L-alanyl-L-threonyl-L-asparaginyl-L-alanyl-L-glutaminyl-L-isoleucyl-L-leucyl-L-alanyl-L-histidyl-L-valinamide, trifluoroacetate salt
Molecular Formula
C187H320N56O50 • XCF3COOH
Formula Weight
4152.9
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC([C@@]([C@H](CC)C)([H])NC([C@H](CCC(N)=O)NC([C@@H](NC([C@H](CC(N)=O)NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@@]([C@H](CC)C)([H])NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(CNC([C@@]([C@H](CC)C)([H])NC([C@@H]1CCCN1C([C@H](C(C)C)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@@]([C@H](CC)C)([H])NC([C@H](C(C)C)N[H])=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)CC2=CC=C(O)C=C2)=O)=O)C)=O)C)=O)=O)=O)=O)C)=O)C)=O)=O)=O)C)=O)=O)=O)=O)C)=O)CC3=CN=CN3)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C187H320N56O50.C2HF3O2/c1-37-95(25)143(240-177(286)131-51-46-68-243(131)184(293)142(94(23)24)237-175(284)129(80-139(255)256)230-169(278)122(73-89(13)14)227-176(285)130(83-244)235-171(280)124(75-91(17)18)233-182(291)146(98(28)40-4)241-178(287)140(194)92(19)20)179(288)206-82-137(252)215-118(69-85(5)6)166(275)225-120(71-87(9)10)167(276)220-113(50-45-67-205-187(200)201)162(271)238-144(96(26)38-2)181(290)232-123(74-90(15)16)170(279)226-121(72-88(11)12)168(277)223-117(59-63-138(253)254)161(270)221-114(56-60-132(189)247)157(266)212-102(32)152(261)217-111(48-43-65-203-185(196)197)159(268)228-125(76-107-52-54-109(246)55-53-107)172(281)219-110(47-41-42-64-188)156(265)210-99(29)149(258)208-101(31)151(260)216-112(49-44-66-204-186(198)199)160(269)229-128(79-136(193)251)173(282)222-115(57-61-133(190)248)158(267)211-100(30)150(259)209-105(35)155(264)242-147(106(36)245)183(292)234-127(78-135(192)250)165(274)214-103(33)153(262)218-116(58-62-134(191)249)163(272)239-145(97(27)39-3)180(289)231-119(70-86(7)8)164(273)213-104(34)154(263)224-126(77-108-81-202-84-207-108)174(283)236-141(93(21)22)148(195)257;3-2(4,5)1(6)7/h52-55,81,84-106,110-131,140-147,244-246H,37-51,56-80,82-83,188,194H2,1-36H3,(H2,189,247)(H2,190,248)(H2,191,249)(H2,192,250)(H2,193,251)(H2,195,257)(H,202,207)(H,206,288)(H,208,258)(H,209,259)(H,210,265)(H,211,267)(H,212,266)(H,213,273)(H,214,274)(H,215,252)(H,216,260)(H,217,261)(H,218,262)(H,219,281)(H,220,276)(H,221,270)(H,222,282)(H,223,277)(H,224,263)(H,225,275)(H,226,279)(H,227,285)(H,228,268)(H,229,269)(H,230,278)(H,231,289)(H,232,290)(H,233,291)(H,234,292)(H,235,280)(H,236,283)(H,237,284)(H,238,271)(H,239,272)(H,240,286)(H,241,287)(H,242,264)(H,253,254)(H,255,256)(H4,196,197,203)(H4,198,199,204)(H4,200,201,205);(H,6,7)/t95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106+,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,140-,141-,142-,143-,144-,145-,146-,147-;/m0./s1
InChi Key
OREOSNBCOKCDTJ-FWBCUHGPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $401

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    Product Description

    Urocortin II is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF, urocortin (Item No. 24744), urocortin III (Item Nos. 24748 | 24749 | 24750), frog sauvagine, and piscine urotensin I.1 Mouse urocortin II shares 34 and 42% sequence homology with rat CRF and urocortin (Item No. 24745). It is expressed in mouse paraventricular, supraoptic, and arcuate nuclei of the hypothalamus, the locus coeruleus, and in motor nuclei of the brainstem and spinal ventral horn. Urocortin II selectively binds to CRF1 over CRF2 receptors (Kis = 0.66 and >100 nM, respectively) and induces cAMP production in CHO cells expressing CRF2 (EC50 = 0.14 nM). In vivo, urocortin II suppresses nighttime food intake by 35% in rats when administered intracerebroventricularly at a dose of 1 μg. Urocortin II (0.1 and 0.5 μg, i.c.v) stimulates fecal pellet output, increases distal colonic transit, and inhibits gastric emptying in mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Reyes, T.M., Lewis, K., Perrin, M.H., et al. Urocortin II: A member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Proc. Natl. Acad. Sci. USA 98(5), 2843-2848 (2001).

    2. Martinez, V., Wang, L., Million, M., et al. Urocortins and the regulation of gastrointestinal motor function and visceral pain. Peptides 25(10), 1733-1744 (2004).