A neuropeptide hormone
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Urocortin II (human) (trifluoroacetate salt)

Item No. 24746

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-isoleucyl-L-valyl-L-leucyl-L-seryl-L-leucyl-L-α-aspartyl-L-valyl-L-prolyl-L-isoleucylglycyl-L-leucyl-L-leucyl-L-glutaminyl-L-isoleucyl-L-leucyl-L-leucyl-L-α-glutamyl-L-glutaminyl-L-alanyl-L-arginyl-L-alanyl-L-arginyl-L-alanyl-L-alanyl-L-arginyl-L-α-glutamyl-L-glutaminyl-L-alanyl-L-threonyl-L-threonyl-L-asparaginyl-L-alanyl-L-arginyl-L-isoleucyl-L-leucyl-L-alanyl-L-arginyl-L-valylglycyl-L-histidyl-L-cysteine, trifluoroacetate salt
CAS Number
398001-88-2
Molecular Formula
C194H339N63O54S • XCF3COOH
Formula Weight
4450.2
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
NC([C@@H](NC([C@@H](NC(CNC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CC(C)C)NC([C@@]([C@H](CC)C)([H])NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CC(N)=O)NC([C@@]([C@@H](C)O)([H])NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CCC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@@]([C@H](CC)C)([H])NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(CNC([C@@]([C@H](CC)C)([H])NC([C@@H]1CCCN1C([C@H](C(C)C)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@@]([C@H](CC)C)([H])N[H])=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)C)=O)=O)C)=O)C)=O)=O)=O)=O)C)=O)=O)=O)=O)C)=O)=O)=O)=O)C)=O)=O)=O)=O)CC2=CN=CN2)=O)CS)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C194H339N63O54S.C2HF3O2/c1-38-96(25)142(199)181(303)250-144(94(21)22)184(306)243-126(76-92(17)18)176(298)247-130(83-258)179(301)241-124(74-90(13)14)174(296)242-129(79-141(271)272)178(300)251-145(95(23)24)189(311)257-69-47-53-132(257)180(302)254-146(97(26)39-2)183(305)218-82-137(265)227-120(70-86(5)6)171(293)239-122(72-88(9)10)172(294)237-117(56-61-135(197)263)168(290)253-148(99(28)41-4)186(308)245-125(75-91(15)16)175(297)240-123(73-89(11)12)173(295)238-119(58-63-140(269)270)165(287)235-115(54-59-133(195)261)161(283)223-103(32)155(277)230-111(49-43-65-213-191(203)204)160(282)222-102(31)154(276)229-110(48-42-64-212-190(201)202)159(281)221-100(29)152(274)220-101(30)153(275)231-112(50-44-66-214-192(205)206)163(285)236-118(57-62-139(267)268)164(286)234-116(55-60-134(196)262)162(284)224-106(35)158(280)255-150(108(37)260)188(310)256-149(107(36)259)187(309)246-128(78-136(198)264)170(292)226-105(34)157(279)233-114(52-46-68-216-194(209)210)167(289)252-147(98(27)40-3)185(307)244-121(71-87(7)8)169(291)225-104(33)156(278)232-113(51-45-67-215-193(207)208)166(288)249-143(93(19)20)182(304)217-81-138(266)228-127(77-109-80-211-85-219-109)177(299)248-131(84-312)151(200)273;3-2(4,5)1(6)7/h80,85-108,110-132,142-150,258-260,312H,38-79,81-84,199H2,1-37H3,(H2,195,261)(H2,196,262)(H2,197,263)(H2,198,264)(H2,200,273)(H,211,219)(H,217,304)(H,218,305)(H,220,274)(H,221,281)(H,222,282)(H,223,283)(H,224,284)(H,225,291)(H,226,292)(H,227,265)(H,228,266)(H,229,276)(H,230,277)(H,231,275)(H,232,278)(H,233,279)(H,234,286)(H,235,287)(H,236,285)(H,237,294)(H,238,295)(H,239,293)(H,240,297)(H,241,301)(H,242,296)(H,243,306)(H,244,307)(H,245,308)(H,246,309)(H,247,298)(H,248,299)(H,249,288)(H,250,303)(H,251,300)(H,252,289)(H,253,290)(H,254,302)(H,255,280)(H,256,310)(H,267,268)(H,269,270)(H,271,272)(H4,201,202,212)(H4,203,204,213)(H4,205,206,214)(H4,207,208,215)(H4,209,210,216);(H,6,7)/t96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107+,108+,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,
InChi Key
HZIVAMJUHUOKBO-HOTOWTTASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    Urocortin II is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF, urocortin (Item No. 24745), urocortin III (Item Nos. 24749 | 24750), frog sauvagine, and piscine urotensin I.1 Human urocortin II shares 34, 43, and 37-40% sequence homology with rat and human CRF, human urocortin (Item No. 24744), and human urocortin III (Item No. 24748). Urocortin II increases cell shortening and accelerates relaxation of rabbit ventricular myocytes in a time- and concentration-dependent manner. In vivo, urocortin reduces arterial blood pressure in normotensive and spontaneously hypertensive rats via peripheral CRF2 receptor agonism. It induces dose-dependent tachycardia and hypotension in rats when administered at doses of 3 and 30 pmol/kg.2 Urocortin (10 and 20 μg/kg) also reduces the visceral pain response to colorectal distension in conscious rats and delays gastric emptying in mice.1,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Adão, R., Santos-Ribeiro, D., Rademaker, M.T., et al. Urocortin 2 in cardiovascular health and disease. Drug Discov. Today 20(7), 906-914 (2015).

    2. Gardiner, S.M., March, J.E., Kemp, P.A., et al. Regional hemodynamic actions of selective corticotropin-releasing factor type 2 receptor ligands in conscious rats. J. Pharmacol. Exp. Ther. 312(1), 53-60 (2005).

    3. Million, M., Wang, L., Wang, Y., et al. CRF2 receptor activation prevents colorectal distension induced visceral pain and spinal ERK1/2 phosphorylation in rats. Gut 55(2), 172-181 (2006).