A neuropeptide
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[Ser4,Ile8]-Oxytocin (trifluoroacetate salt)

Item No. 24767

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-L-serine-8-L-isoleucine-oxytocin, trifluoroacetate salt
Synonyms
  • Isotocin
Molecular Formula
C41H63N11O12S2 • XCF3COOH
Formula Weight
966.1
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC(CNC([C@@]([C@H](CC)C)([H])NC([C@@H]1CCCN1C([C@@H](N2)CSSC[C@H](N[H])C(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C2=O)=O)=O)=O)CC3=CC=C(O)C=C3)=O)=O)=O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C41H63N11O12S2.C2HF3O2/c1-5-20(3)32(39(62)45-16-31(44)56)51-38(61)29-8-7-13-52(29)41(64)28-19-66-65-18-24(42)34(57)46-25(14-22-9-11-23(54)12-10-22)36(59)50-33(21(4)6-2)40(63)48-27(17-53)37(60)47-26(15-30(43)55)35(58)49-28;3-2(4,5)1(6)7/h9-12,20-21,24-29,32-33,53-54H,5-8,13-19,42H2,1-4H3,(H2,43,55)(H2,44,56)(H,45,62)(H,46,57)(H,47,60)(H,48,63)(H,49,58)(H,50,59)(H,51,61);(H,6,7)/t20-,21-,24-,25-,26-,27-,28-,29-,32-,33-;/m0./s1
InChi Key
HZGFKIAVKSCMJC-XTYGDVRLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $103

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    [Ser4,Ile8]-Oxytocin is a neuropeptide and analog of oxytocin (Item No. 11799).1,2,3 In vivo, [Ser4,Ile8]-oxytocin increases activity of slow-firing oxytocin neurons and triggers the milk ejection reflex in female rats when injected into the third ventricle at a dose of 1 ng.1 It induces uterine contraction in female rats and prevents penile erection and yawning in male rats.2 [Ser4,Ile8]-Oxytocin also decreases blood glucose, glucose intolerance, and hyperinsulinemia without affecting body weight in mice with high-fat diet-induced type 2 diabetes.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Freund-Mercier, M.J., and Richard, P. Electrophysiological evidence for facilitatory control of oxytocin neurones by oxytocin during suckling in the rat. J. Physiol. 352, 447-466 (1984).

    2. Argiolas, A., Melis, M.R., Stancampiano, R., et al. Penile erection and yawning induced by oxytocin and related peptides: Structure-activity relationship. Peptides 10(3), 559-563 (1989).

    3. Zhou, Y., Rodriguez, A.L., Williams, R., et al. Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS. Bioorg. Med. Chem. Lett. 19(23), 6502-6506 (2009).