A gastrointestinal hormone and neuropeptide
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Secretin (human) (trifluoroacetate salt)

Item No. 24990

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Molecular Formula
C130H220N44O40 • XCF3COOH
Formula Weight
3039.4
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC([C@H](C(C)C)NC([C@H](CC(C)C)NC(CNC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](NC(CNC([C@H](CCC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](CO)NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC(CNC([C@@H](NC([C@H](CO)NC([C@@H](N[H])CC1=CN=CN1)=O)=O)CC(O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C130H220N44O40.C2HF3O2/c1-60(2)43-81(120(208)173-100(66(13)14)103(134)191)153-95(183)54-149-106(194)77(31-35-92(132)180)159-116(204)84(46-63(7)8)166-118(206)85(47-64(9)10)164-111(199)75(29-23-41-146-129(139)140)155-113(201)79(32-36-93(133)181)160-117(205)83(45-62(5)6)162-110(198)73(27-21-39-144-127(135)136)154-104(192)67(15)152-94(182)53-148-107(195)78(33-37-97(185)186)158-109(197)74(28-22-40-145-128(137)138)156-115(203)82(44-61(3)4)163-112(200)76(30-24-42-147-130(141)142)157-122(210)90(57-176)170-119(207)86(48-65(11)12)165-114(202)80(34-38-98(187)188)161-123(211)91(58-177)171-126(214)102(69(17)179)174-121(209)87(49-70-25-19-18-20-26-70)168-125(213)101(68(16)178)172-96(184)55-150-108(196)88(51-99(189)190)167-124(212)89(56-175)169-105(193)72(131)50-71-52-143-59-151-71;3-2(4,5)1(6)7/h18-20,25-26,52,59-69,72-91,100-102,175-179H,21-24,27-51,53-58,131H2,1-17H3,(H2,132,180)(H2,133,181)(H2,134,191)(H,143,151)(H,148,195)(H,149,194)(H,150,196)(H,152,182)(H,153,183)(H,154,192)(H,155,201)(H,156,203)(H,157,210)(H,158,197)(H,159,204)(H,160,205)(H,161,211)(H,162,198)(H,163,200)(H,164,199)(H,165,202)(H,166,206)(H,167,212)(H,168,213)(H,169,193)(H,170,207)(H,171,214)(H,172,184)(H,173,208)(H,174,209)(H,185,186)(H,187,188)(H,189,190)(H4,135,136,144)(H4,137,138,145)(H4,139,140,146)(H4,141,142,147);(H,6,7)/t67-,68+,69+,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,100-,101-,102-;/m0./s1
InChi Key
DCBXYTSZIOOWBE-ZJWADALWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $281

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    Product Description

    Secretin is an endogenous 27-amino acid gastrointestinal hormone and neuropeptide that regulates secretion from the stomach, pancreas, and liver.1,2 It belongs to the secretin/glucagon superfamily of peptides, which includes glucagon (Item No. 24204), glucagon-like peptide-1 (GLP-1; Item No. 24460), GLP-2 (Item No. 24414), and pituitary adenylate cyclase-activating polypeptide (PACAP; Item Nos. 24769 | 24770).3 Secretin dose-dependently increases somatostatin release from primary human antral cells in vitro.4 In vivo, secretin dose-dependently increases the volume of pancreatic secretion as well as inhibits gastric acid secretion induced by gastrin I (Item No. 24457) in rats when administered at a dose of 100 pmol/kg per h.5 Secretin (40 μg/kg, i.v.) increases the number of neurons expressing c-fos in the central amygdala and area postrema in rats.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kopin, A.S., Wheeler, M.B., and Leiter, A.B. Secretin: Structure of the precursor and tissue distribution of the mRNA. Proc. Natl. Acad. Sci. USA 87(6), 2299-2303 (1990).

    2. Sekar, R., and Chow, B.K. Metabolic effects of secretin. Gen. Comp. Endocrinol. 181, 18-24 (2013).

    3. Vaudry, D., Falluel-Morel, A., Bourgault, S., et al. Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery. Pharmacol. Rev. 61(3), 283-357 (2009).

    4. Buchan, A.M., Meloche, R.M., Kwok, Y.N., et al. Effect of cholecystokinin and secretin on somatostatin release from cultured antral cells. Gastroenterology 104(5), 1414-1419 (1993).

    5. Solomon, T.E., Keire, D.A., Gong, P., et al. Receptor subtypes: Species variations in secretin affect potency for pancreatic but not gastric secretion. Pancreas 26(3), 300-305 (2003).

    6. Goulet, M., Shiromani, P.J., Ware, C.M., et al. A secretin i.v. infusion activates gene expression in the central amygdala of rats. Neuroscience 118(4), 881-888 (2003).