A cyclic neuropeptide hormone
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Somatostatin-28 (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

Item No. 24991

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Molecular Formula
C137H207N41O39S3 • XCF3COOH
Formula Weight
3148.6
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
[H]N[C@@H](CO)C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N1CCC[C@H]1C(N[C@H](C(N[C@H](C(N[C@H](C(N2CCC[C@H]2C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CO)C3=O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)CC5=CNC6=C5C=CC=C6)=O)CC7=CC=CC=C7)=O)CC8=CC=CC=C8)=O)=O)=O)CSSC[C@H](N3)C(O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)C)=O)CCSC)=O)C)=O)=O)=O)=O)=O)C)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C137H207N41O39S3.C2HF3O2/c1-69(154-113(194)82(37-19-22-47-138)159-115(196)85(40-25-50-149-136(145)146)160-118(199)87(44-45-106(188)189)163-116(197)86(41-26-51-150-137(147)148)164-130(211)101-43-27-52-177(101)133(214)72(4)156-114(195)88(46-54-218-7)158-110(191)71(3)155-129(210)100-42-28-53-178(100)134(215)95(61-104(144)186)171-126(207)96(65-180)172-124(205)93(59-102(142)184)165-111(192)70(2)153-112(193)80(141)64-179)109(190)152-63-105(187)157-98-67-219-220-68-99(135(216)217)174-127(208)97(66-181)173-132(213)108(74(6)183)176-125(206)91(57-77-33-15-10-16-34-77)170-131(212)107(73(5)182)175-119(200)84(39-21-24-49-140)161-122(203)92(58-78-62-151-81-36-18-17-35-79(78)81)168-121(202)90(56-76-31-13-9-14-32-76)166-120(201)89(55-75-29-11-8-12-30-75)167-123(204)94(60-103(143)185)169-117(198)83(162-128(98)209)38-20-23-48-139;3-2(4,5)1(6)7/h8-18,29-36,62,69-74,80,82-101,107-108,151,179-183H,19-28,37-61,63-68,138-141H2,1-7H3,(H2,142,184)(H2,143,185)(H2,144,186)(H,152,190)(H,153,193)(H,154,194)(H,155,210)(H,156,195)(H,157,187)(H,158,191)(H,159,196)(H,160,199)(H,161,203)(H,162,209)(H,163,197)(H,164,211)(H,165,192)(H,166,201)(H,167,204)(H,168,202)(H,169,198)(H,170,212)(H,171,207)(H,172,205)(H,173,213)(H,174,208)(H,175,200)(H,176,206)(H,188,189)(H,216,217)(H4,145,146,149)(H4,147,148,150);(H,6,7)/t69-,70-,71-,72-,73+,74+,80-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,107-,108-;/m0./s1
InChi Key
JHZHKNYIHIRNHG-LQDYQFHQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    500 µg

    $196

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    Product Description

    Somatostatin-28 is a cyclic neuropeptide hormone that has a role in endocrine regulation.1 It is a somatostatin (SST) receptor agonist that binds to SST1, SST2, SST3, SST4, and SST5 (IC50s = 0.60, 0.12, 0.22, 0.83, and 0.41 nM, respectively, in CCL39 cells expressing human recombinant receptors).2 It inhibits cAMP accumulation induced by forskolin (Item No. 11018) in CCL39 cells expressing human recombinant SST1, SST2, SST3, SST4, and SST5 (EC50s = 5.13, 1.91, 6.46, 2.95, and 3.55 nM, respectively).3 Somatostatin-28 stimulates growth hormone (GH) release from primary porcine pituitary cells when used at a concentration of 1 fM.4 It inhibits acid secretion induced by gastrin I (Item No. 24457) and IBMX (Item No. 13347) in isolated rat gastric mucosa (EC50s = 27 and 252 nM, respectively).5 In vivo, somatostatin-28 dose-dependently increases basal and pentagastrin-induced gastric acid secretion in rats.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lucey, M.R. Endogenous somatostatin and the gut. Gut 27(4), 457-467 (1986).

    2. Siehler, S., Seuwen, K., and Hoyer, D. Characterisation of human recombinant somatostatin receptors. 1. Radioligand binding studies. Naunyn Schmiedebergs Arch. Pharmacol. 360(5), 488-499 (1999).

    3. Siehler, S., and Hoyer, D. Characterisation of human recombinant somatostatin receptors. 3. Modulation of adenylate cyclase activity. Naunyn Schmiedebergs Arch. Pharmacol. 360(5), 510-521 (1999).

    4. Ramírez, J.L., Torronteras, R., Castaño, J.P., et al. Somatostatin plays a dual, stimulatory/inhibitory role in the control of growth hormone secretion by two somatotrope subpopulations from porcine pituitary. J. Neuroendocrinol. 9(11), 841-848 (1997).

    5. Wyatt, M.A., Jarvie, E., Feniuk, W., et al. Somatostatin sst2 receptor-mediated inhibition of parietal cell function in rat isolated gastric mucosa. Br. J. Pharmacol. 119(5), 905-910 (1996).

    6. Seefried, G., Schmidtler, J., and Schwille, P.O. Gastric secretion and gastrin under progressive doses of somatostatin-14 and -28 administered intraperitoneally to the rat. Peptides 9(2), 249-255 (1988).