An antagonist of the thrombin receptor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Thrombin Receptor Peptide Ligand (trifluoroacetate salt)

Item No. 24995

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-alanyl-L-phenylalanyl-L-leucyl-L-alanyl-L-arginyl-L-alanyl-L-alanine, trifluoroacetate salt
Synonyms
  • AFLARAA
  • Ala-Phe-Leu-Ala-Arg-Ala-Ala
Molecular Formula
C33H54N10O8 • XCF3COOH
Formula Weight
718.8
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
N[C@@H](C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@H](C(N[C@@H](C)C(N[C@H](C(N[C@@H](C)C(N[C@@H](C)C(O)=O)=O)=O)CCCNC(N)=N)=O)=O)CC(C)C)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C33H54N10O8.C2HF3O2/c1-17(2)15-24(43-31(49)25(42-26(44)18(3)34)16-22-11-8-7-9-12-22)30(48)39-20(5)28(46)41-23(13-10-14-37-33(35)36)29(47)38-19(4)27(45)40-21(6)32(50)51;3-2(4,5)1(6)7/h7-9,11-12,17-21,23-25H,10,13-16,34H2,1-6H3,(H,38,47)(H,39,48)(H,40,45)(H,41,46)(H,42,44)(H,43,49)(H,50,51)(H4,35,36,37);(H,6,7)/t18-,19-,20-,21-,23-,24-,25-;/m0./s1
InChi Key
NYJFFJOZEDVBPN-WUQYVZKUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $112

    Add
    Product Description

    Thrombin receptor peptide ligand is antagonist of the thrombin receptor (EC50s = 16-33 µM to inhibit platelet aggregation in vitro).1 It inhibits α-thrombin and platelet aggregation induced by thrombin receptor activating peptide (TRAP; Item No. 24125) in vitro when used at a concentration of 32 µM but does not affect platelet aggregation induced by ADP or collagen. It also inhibits thrombin- and TRAP-induced proliferation of vascular smooth muscle cells (VSMCs).2 Thrombin receptor peptide ligand (100 µmol/kg bolus, i.v., plus 900 µmol/kg infusion) inhibits arterial thrombosis in a rabbit model of partial carotid artery occlusion without increasing bleeding time.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pakala, R., Liang, T.C., and Benedict, C.R. A peptide ligand of the human thrombin receptor antagonizes thrombin receptor activating peptide and α-thrombin-induced platelet aggregation. Fibrinolysis Proteol. 14(1), 15-21 (2000).

    2. Pakala, R., Liang, C.T., and Benedict, C.R. A peptide analogue of thrombin receptor-activating peptide inhibits thrombin and thrombin-receptor-activating peptide-induced vascular smooth muscle cell proliferation. J. Cardiovasc. Pharmacol. 37(5), 619-629 (2001).

    3. Pakala, R., Liang, C.T., and Benedict, C.R. Inhibition of arterial thrombosis by a peptide ligand of the thrombin receptor. Thromb. Res. 100(1), 89-96 (20000).