Kaempferol-3-glucoside

Kaempferol-3-glucoside is an orally bioavailable flavonoid that has been isolated from the leaves of D. kaki and R. agrestis and has anti-inflammatory activity.^1,2 Kaempferol-3-glucoside (20-80 µg/ml) dose-dependently inhibits IL-1β-stimulated nitric oxide and prostaglandin E₂ (PGE₂; Item No. 14010) production in patient-derived osteoarthritis chondrocytes, an effect that is blocked by the PPAR-γ inhibitor GW 9662 (Item No. 70785).² It also inhibits IL-1β-stimulated expression of nitric oxide synthase (NOS) and COX-2 and activation of MAPK and NF-κB signaling. Kaempferol-3-glucoside (1-20 µM) dose-dependently prevents the loss of E-cadherin, expression of vimentin, and production of collagen type-1 in hydrogen peroxide-exposed human bronchial epithelial cells in vitro.³ Kaempferol-3-glucoside (1.5 mg/kg, p.o.) inhibits ear swelling and the production of IL-2 and IL-4 as well as reduces serum IgE levels in a mouse model of atopic dermatitis.¹ Kaempferol-3-glucoside (10-20 mg/kg, p.o.) also reduces reactive oxygen species (ROS) production, collagen fiber deposition, and autophagosome formation in the epithelial lung tissue of ovalbumin-challenged mice.³

WARNING This product is not for human or veterinary use.

1. Kotani, M., Matsumoto, M., Fujita, A., et al. Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice. J. Allergy Clin. Immunol. 106(1 Pt 1), 159-166 (2000).

2. Ma, Z., Piao, T., Wang, Y., et al. Astragalin inhibits IL-1β-induced inflammatory mediators production in human osteoarthritis chondrocyte by inhibiting NF-κB and MAPK activation. Int. Immunopharmacol. 25(1), 83-87 (2015).

3. Cho, I.-H., Choi, Y.-J., Gong, J.-H., et al. Astragalin inhibits autophagy-associated airway epithelial fibrosis. Respir. Res. 16:51, (2015).