A phytochemical with diverse biological activities
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Decursin

Item No. 25214

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-methyl-2-butenoic acid, (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-pyrano[3,2-g]-1-benzopyran-7-yl ester
CAS Number
5928-25-6
Synonyms
  • (+)-Decursin
Molecular Formula
C19H20O5
Formula Weight
328.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 2 mg/mlEthanol: 2 mg/ml
λmax
220, 330 nm
SMILES
O=C1C=CC(C=C(C[C@H](OC(/C=C(C)\C)=O)C(C)(C)O2)C2=C3)=C3O1
InChi Code
InChI=1S/C19H20O5/c1-11(2)7-18(21)23-16-9-13-8-12-5-6-17(20)22-14(12)10-15(13)24-19(16,3)4/h5-8,10,16H,9H2,1-4H3/t16-/m0/s1
InChi Key
CUKSFECWKQBVED-INIZCTEOSA-N
Origin
Plant/Angelicae sinensis Radix
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

    $462

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Decursin is a phytochemical originally isolated from A. gigas with diverse biological activities.1,2,3,4,5 It reduces the growth of B16/F10 murine melanoma cells, but not NIH-3T3 fibroblasts, via induction of apoptosis and increased caspase-3 activity when used at concentrations ranging from 40 to 100 μM.1 In vivo, decursin (10 mg/kg, i.p.) reduces tumor growth in a B16/F10 mouse xenograft model. Decursin inhibits RANKL-induced osteoclast differentiation and decreases fusion and migrations of pre-osteoclasts in vitro and prevents LPS-induced bone erosion in mice.2 In a mouse model of seizures induced by kainic acid (Item No. 78050), decursin (20 mg/kg) increases latency to the first electroencephalographic (EEG) discharge and attenuates the intensity and reduces the frequency of seizure discharges in the parietal cortex.3 Decursin inhibits tube formation and expression of VEGF receptor 2 (VEGFR2) in human retinal microvascular endothelial cells (HRMECs) and human umbilical vein endothelial cells (HUVECs) in vitro and reduces retinal expression of VEGFR2 and neovascularization in rats with diabetes induced by streptozotocin (Item No. 13104).4 It also reduces hepatic collagen expression, serum levels of ALT, AST, and ALP, and production of reactive oxygen species (ROS) in a mouse model of CCL4-induced liver fibrosis.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kim, B.S., Seo, H., Kim, H.-J., et al. Decursin from Angelica gigas nakai inhibits B16F10 melanoma growth through induction of apoptosis. J. Med. Food. 18(10), 1121-1127 (2015).

    2. Kim, K.-J., Yeon, J.-T., Choi, S.-W., et al. Decursin inhibits osteoclastogenesis by downregulating NFATc1 and blocking fusion of pre-osteoclasts. Bone 81, 208-216 (2015).

    3. Lee, J.-K., Jeong, J.W., Jang, T., et al. Decursin attenuates kainic acid-induced seizures in mice. Neuroreport 25(16), 1243-1249 (2014).

    4. Yang, Y., Yang, K., Li, Y., et al. Decursin inhibited proliferation and angiogenesis of endothelial cells to suppress diabetic retinopathy via VEGFR2. Mol. Cell. Endocrinol. 378(1-2), 46-52 (2013).

    5. Choi, Y.J., Kim, D.H., Kim, S.J., et al. Decursin attenuates hepatic fibrogenesis through interrupting TGF-beta-mediated NAD(P)H oxidase activation and Smad signaling in vivo and in vitro. Life Sci. 108(2), 94-103 (2014).