A steroid sapogenin with diverse biological activities
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Ruscogenin

Item No. 25217

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1β,3β,25R)-spirost-5-ene-1,3-diol
CAS Number
472-11-7
Molecular Formula
C27H42O4
Formula Weight
430.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 2 mg/ml
SMILES
C[C@H](CC1)CO[C@]21O[C@@]3([H])C[C@@]4([H])[C@]5([H])CC=C6C[C@@H](O)C[C@@H](O)[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@@]3([H])[C@@H]2C
InChi Code
InChI=1S/C27H42O4/c1-15-7-10-27(30-14-15)16(2)24-22(31-27)13-21-19-6-5-17-11-18(28)12-23(29)26(17,4)20(19)8-9-25(21,24)3/h5,15-16,18-24,28-29H,6-14H2,1-4H3/t15-,16+,18-,19-,20+,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChi Key
QMQIQBOGXYYATH-IDABPMKMSA-N
Origin
Plant/Ophiopogonis radix
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $153

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    10 mg

    $268

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    25 mg

    $587

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Ruscogenin is a steroid sapogenin that has been found in O. japonicus with diverse biological activities.1,2,3,4,5 It reduces adhesion of HL-60 cells to ECV304 cells induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) with an IC50 value of 7.76 nM and decreases peritoneal leukocyte migration induced by zymosan A (Item No. 21175) in mice when administered at a dose of 5 mg/kg.1 Oral administration of ruscogenin (12.5 mg/kg) inhibits ADP-induced platelet aggregation in rats.2 Ruscogenin prevents monocrotaline-induced increases in mean arterial pressure (MAP), expression of IL-1β and TNF in plasma and lung, and endothelial cell apoptosis in pulmonary arterioles in a rat model of pulmonary hypertension.3 It also reduces proteinuria and renal macrophage infiltration in a rat model of diabetes induced by streptozotocin (Item No. 13104) and decreases gene expression of inflammatory cytokines, dyslipidemia, and liver steatosis in a hamster model of high-fat diet-induced nonalcoholic steatohepatitis (NASH).4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kou, J., Sun, Y., Lin, Y., et al. Anti-inflammatory activities of aqueous extract from Radix Ophiopogon japonicus and its two constituents. Biol. Pharm. Bull. 28(7), 1234-1238 (2005).

    2. Kou, J., Tian, Y., Tang, Y., et al. Antithrombotic activities of aqueous extract from Radix Ophiopogon japonicus and its two constituents. Biol. Pharm. Bull. 29(6), 1267-1270 (2006).

    3. Bi, L.-Q., Zhu, R., Kong, H., et al. Ruscogenin attenuates monocrotaline-induced pulmonary hypertension in rats. Int. Immunopharmacol. 16(1), 7-16 (2013).

    4. Lu, H.-H., Tzeng, T.-F., Liou, S.-S., et al. Ruscogenin ameliorates diabetic nephropathy by its anti-inflammatory and anti-fibrotic effects in streptozotocin-induced diabetic rat. BMC Complement. Altern. Med. 14:110, (2014).

    5. Lu, H.-J., Tzeng, T.-F., Liou, S.-S., et al. Ruscogenin ameliorates experimental nonalcoholic steatohepatitis via suppressing lipogenesis and inflammatory pathway. Biomed. Res. Int. 652680 (2014).