Methiocarb

Methiocarb is a carbamate pesticide.¹ It inhibits the activity of acetylcholinesterase (AChE) from methiocarb-resistant and -sensitive western flower thrips (F. occidentalis; IC₅₀s = 0.43 and 2.1 µM, respectively) and is toxic to the same strains (LC₅₀s = 31.1 and 3.26 ppm for the resistant- and sensitive strains, respectively). Methiocarb is also toxic to the land snail (M. obstructa; LD₅₀ = 27.4 μg/animal) and induces 94% mortality in citrus mites (A. pelekassi) when used at a concentration of 0.5 ppm.^2,3 It is an estrogen receptor α (ERα) and ERβ agonist (EC₂₀s = 19.87 and 20.24 μM, respectively) and androgen receptor antagonist (IC₅₀ = 13.89 μM) in cell-based reporter assays.⁴ It is toxic to juvenile rainbow trout and guppies with LC₅₀ values of 0.795 and 1.482 mg/L, respectively, at 48 hours of exposure.⁵ Formulations containing methiocarb have been used in the control of mollusks, mites, and insects in residential and commercial settings.

WARNING This product is not for human or veterinary use.

1. Jensen, S.E. Acetylcholinesterase activity associated with methiocarb resistance in a strain of western flower thrips, Frankliniella occidentalis (Pergande). Pesicide Biochem. Physiol. 61(3), 191-200 (1998).

2. Hussein, H.I., Al-Rajhy, D., El-Shahawi, F.I., et al. Molluscicidal activity of Pergularia tomentosa (L.), methomyl and methiocarb, against land snails. Int. J. Pest Mgt. 45(3), 211-213 (2010).

3. Reed, D.K., Crittenden, C.R., and Lyon, D.J. Acaricides screened against two rust mites of citrus. J. Econ. Entomol. 60(3), 668-671 (1967).

4. Tange, S., Fujimoto, N., Uramaru, N., et al. In vitro metabolism of methiocarb and carbaryl in rats, and its effect on their estrogenic and antiandrogenic activities. Environ. Toxicol. Pharmacol. 41, 289-297 (2016).

5. Boran, M., Altinok, I., and Capkin, E. Acute toxicity of carbaryl, methiocarb, and carbosulfan to the rainbow trout (Oncorhynchus mykiss) and guppy (Poecilia reticulata). Turk. J. Vet. Animal Sci. 31(1), 39-45 (2007).