A fungicide
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Labeled Version(s)
39604Spiroxamine-d4
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Spiroxamine

Item No. 25823

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-(1,1-dimethylethyl)-N-ethyl-N-propyl-1,4-dioxaspiro[4.5]decane-2-methanamine
CAS Number
118134-30-8
Molecular Formula
C18H35NO2
Formula Weight
297.5
Purity
≥95%
Formulation
An oil
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly Soluble
SMILES
CCN(CC1COC2(CCC(C(C)(C)C)CC2)O1)CCC
InChi Code
InChI=1S/C18H35NO2/c1-6-12-19(7-2)13-16-14-20-18(21-16)10-8-15(9-11-18)17(3,4)5/h15-16H,6-14H2,1-5H3
InChi Key
PUYXTUJWRLOUCW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Spiroxamine is a tertiary amine fungicide and an inhibitor of Δ14 reductase/Δ8→Δ7 isomerase.1 It inhibits the growth of N. parvum, B. dothidea, D. seriata, and L. theobromae isolates from grape vines (EC50s = 0.97-10.28 mg/L).2 Spiroxamine (0.03-30 μM) reduces network formation in rat cortical cultures.3 It is also cytotoxic to MDA-kb2 cells (EC20 = 9.29 μM).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sui, G., Zhang, W., Zhou, K., et al. Trialkylamine derivatives containing a triazole moiety as promising ergosterol biosynthesis inhibitor: Design, synthesis, and antifungal activity. Chem. Pharm. Bull. (Tokyo) 65(1), 82-89 (2017).

    2. Amponsah, N.T., Jones, E., Ridgway, H.J., et al. Evaluation of fungicides for the management of Botryosphaeria dieback diseases of grapevines. Pest Manag. Sci. 68(5), 676-683 (2012).

    3. Frank, C.L., Brown, J.P., Wallace, K., et al. Developmental neurotoxicants disrupt activity in cortical networks on microelectrode arrays: Results of screening 86 compounds during neural network formation. Toxicol. Sci. 160(1), 121-135 (2017).

    4. Orton, F., Rosivatz, E., Scholze, M., et al. Widely used pesticides with previously unknown endocrine activity revealed as in vitro antiandrogens. Environ. Health Perspect. 119(6), 794-800 (2011).