A glycerophospholipid
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Phosphatidylglycerol (egg) (sodium salt)

Item No. 25846

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
383907-64-0
Synonyms
  • PGs (egg)
  • L-α-Phosphatidylglycerols (egg)
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: 2 mg/ml
SMILES
[R]C(OC[C@@H](OC([R])=O)COP([O-])(OCC(O)CO)=O)=O.[Na+]
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 mg

    $79

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    50 mg

    $140

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    100 mg

    $234

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    500 mg

    $698

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    Cayman Chemical
    Learn More About Leveraging Helper Lipids to Achieve Versatile LNPs
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    Product Description

    Phosphatidylglycerol is a naturally occurring anionic phospholipid and a constituent of plant, animal, and bacterial cell membranes.1,2 It is less abundant than phosphatidylethanolamine (Item Nos. 16878 | 24332) in prokaryotes and eukaryotes and phosphatidylcholine (Item Nos. 24343 | 24370) in eukaryotes. It is formed via a reaction between CDP-diglyceride with L-α-glycerol 3-phosphate followed by dephosphorylation and is a metabolic precursor of cardiolipin.1 Phosphatidylglycerol species containing polyunsaturated and monounsaturated fatty acyl chains inhibit and promote proliferation of murine keratinocytes, respectively.3 Phosphatidylglycerol is the second largest lipid component of mammalian lung surfactant, comprising 10% of the lipids, and levels are decreased in the lung surfactant of infants with respiratory distress syndrome.2 This product contains phosphatidylglycerol molecular species with variable fatty acyl chain lengths at the sn-1 and sn-2 positions.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ohtsuka, T., Nishijima, M., and Akamatsu, Y. A somatic cell mutant defective in phosphatidylglycerophosphate synthase, with impaired phosphatidylglycerol and cardiolipin biosynthesis. The Journal of Biological Chemisty 268(30), 22908-22913 (1993).

    2. Furse, S. Is phosphatidylglycerol essential for terrestrial life? J. Chem. Biol. 10(1), 1-9 (2016).

    3. Xie, D., Seremwe, M., Edwards, J.G., et al. Distinct effects of different phosphatidylglycerol species on mouse keratinocyte proliferation. PLoS One 9(9), e107119 (2014).

    Product Citations

    Ansar, S.M., Jiang, W., and Mudalige, T. Analysis of verteporfin liposomal formulations for phospholipids and phospholipid degradation products by liquid chromatography-mass spectrometry (LC-MS). J. Pharm. Biomed. Anal. 208, 114473 (2022).