Phosphatidylethanolamine (chicken egg)

Phosphatidylethanolamine is the most abundant phospholipid in prokaryotes and the second most abundant found in the membrane of mammalian, plant, and yeast cells, comprising approximately 25% of total mammalian phospholipids.¹ In the brain, phosphatidylethanolamine comprises almost half of the total phospholipids. It is synthesized mainly through the cytidine diphosphate-ethanolamine and phosphatidylserine decarboxylation pathways, which occur in the endoplasmic reticulum (ER) and mitochondrial membranes, respectively. It is a precursor in the synthesis of phosphatidylcholine and arachidonoyl ethanolamide (Item No. 90050) and is a source of ethanolamine used in various cellular functions. In E. coli, phosphatidylethanolamine deficiency prevents proper assembly of lactose permease, suggesting a role as a lipid chaperone.² It is a cofactor in the propagation of prions in vitro and can convert recombinant mammalian proteins into infectious molecules even in the absence of RNA.³ This product contains phosphatidylcholine molecular species with primarily C16:0 and C18:1 fatty acyl chain lengths. [Matreya, LLC. Catalog No. 1045]

WARNING This product is not for human or veterinary use.

1. Vance, J.E., and Tasseva, G. Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells. Biochim. Biophys. Acta 1831(3), 543-554 (2013).

2. Bogdanov, M., Sun, J., Kaback, H.R., et al. A phospholipid acts as a chaperone in assembly of a membrane transport protein. The Journal of Biological Chemisty 271(20), 11615-11618 (1996).

3. Deleault, N.R., Piro, J.R., Walsh, D.J., et al. Isolation of phosphatidylethanolamine as a solitary cofactor for prion formation in the absence of nucleic acids. Proc. Natl. Acad. Sci. USA 109(22), 8546-8551 (2012).