A CB1 receptor negative allosteric modulator
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

PSNCBAM-1

Item No. 25855

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-chlorophenyl)-N'-[3-[6-(1-pyrrolidinyl)-2-pyridinyl]phenyl]-urea
CAS Number
877202-74-9
Molecular Formula
C22H21ClN4O
Formula Weight
392.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
229, 260, 342 nm
SMILES
ClC1=CC=C(NC(NC2=CC(C3=NC(N4CCCC4)=CC=C3)=CC=C2)=O)C=C1
InChi Code
InChI=1S/C22H21ClN4O/c23-17-9-11-18(12-10-17)24-22(28)25-19-6-3-5-16(15-19)20-7-4-8-21(26-20)27-13-1-2-14-27/h3-12,15H,1-2,13-14H2,(H2,24,25,28)
InChi Key
HDAYFSFWIPRJSO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $40

    Add

    5 mg

    $158

    Add

    10 mg

    $257

    Add

    25 mg

    $492

    Add
    Cannabinoid Resource Center
    Discover Our Tools to Support Cannabinoid Research and Analysis.
    • Cannabinoid signaling research products
    • Analytical standards and certified reference materials
    • Endocannabinoid profiling services
    • Lab wall posters
    • Articles, application notes, and webinars
    LEARN MORE
    Product Description

    PSNCBAM-1 is a cannabinoid 1 (CB1) receptor negative allosteric modulator (NAM).1 It is selective for CB1 over CB2 in HEK293 cells expressing the human receptors (IC50s = 74.3 and >10,000 nM, respectively). PSNCBAM-1 inhibits activation of the CB1 receptor induced by (±)-CP 55,940 (Item No. 13241), anandamide (AEA; Item No. 90050), or 2-arachidonoyl glycerol (2-AG; Item No. 62160) in yeast expressing human CB1 (IC50s = 45.2, 37 and 230.3 nM, respectively). It reduces food intake within one hour and decreases body weight in male rats when administered at a dose of 30 mg/kg. PSNCBAM-1 (10 mg/kg) reduces THC-induced increases in tail-flick latency in mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Horswill, J.G., Bali, U., Shaaban, S., et al. PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats. Br. J. Pharmacol. 152(5), 805-814 (2007).

    2. Gamage, T.F., Farquhar, C.E., Lefever, T.W., et al. The great divide: Separation between in vitro and in vivo effects of PSNCBAM-based CB1 receptor allosteric modulators. Neuropharmacology 125, 365-375 (2017).