A PEGylated derivative of DSPE
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DSPE-PEG(2000)-amine (sodium salt)

Item No. 26000

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • 1,2-Distearoyl-rac-glycero-3-Phosphoethanolamine-N-[amino(polyethylene glycol)-2000]
  • 1,2-Distearoyl Phosphatidylethanolamine-PEG(2000)-amine
  • 1,2-Dioctadecanoyl-rac-glycero-3-Phosphoethanolamine-N-PEG(2000)-amine
  • 1,2-DSPE-PEG(2000)-amine
  • PE(18:0/18:0)-PEG(2000)amine
  • PtdEtn-(1,2-Dioctadecanoyl)-PEG(2000)-amine
Molecular Formula
(C2H4O)nC45H88N2O10P • Na
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 11 mg/mlEthanol: 20 mg/ml
SMILES
CCCCCCCCCCCCCCCCCC(O[C@@H](COP(OCCNC(COCCOCCN)=O)([O-])=O)COC(CCCCCCCCCCCCCCCCC)=O)=O.[Na+]
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $98

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    50 mg

    $315

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    100 mg

    $530

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    Cayman Chemical
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    Product Description

    DSPE-PEG(2000)-amine is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE (DSPE; Item No. 15095). It has been used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents.1,2,3 DSPE-PEG(2000)-amine has also been used in the synthesis of fluorescein isothiocyanate-loaded mesoporous silica nanoparticles for imaging applications.4 It can be conjugated to a variety of functional molecules for improved cellular targeting and uptake of DSPE-PEG(2000)-amine-containing nanoparticles.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sloat, B.R., Sandoval, M.A., Li, D., et al. In vitro and in vivo anti-tumor activities of a gemcitabine derivative carried by nanoparticles. Int. J. Pharm. 409(1-2), 278-288 (2011).

    2. Abd-Rabou, A.A., Bharali, D.J., and Mousa, S.A. Taribavirin and 5-fluorouracil-loaded pegylated-lipid nanoparticle synthesis, p38 docking, and antiproliferative effects on MCF-7 breast cancer. Pharm. Res. 35(4), 76 (2018).

    3. Affram, K., Udofot, O., Singh, M., et al. Smart thermosensitive liposomes for effective solid tumor therapy and in vivo imaging. PLoS One 12(9), e0185116 (2017).

    4. Wang, L.-S., Wu, L.-C., Lu, S.-Y., et al. Biofunctionalized phospholipid-capped mesoporous silica nanoshuttles for targeted drug delivery: Improved water suspensibility and decreased nonspecific protein binding. ACS Nano 4(8), 4371-4379 (2010).

    5. Wen, X., Wang, K., Zhao, Z., et al. Brain-targeted delivery of trans-activating transcriptor-conjugated magnetic PLGA/lipid nanoparticles. PLoS One 9(9), e106652 (2014).